rs41453452

Homo sapiens
G>C
LOC105378901 : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0016 (494/29974,GnomAD)
C=0021 (614/29118,TOPMED)
C=0048 (242/5008,1000G)
C=0014 (54/3854,ALSPAC)
C=0010 (38/3708,TWINSUK)
chr1:110752428 (GRCh38.p7) (1p13.3)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.110752428G>C
GRCh37.p13 chr 1NC_000001.10:g.111295050G>C

Gene: LOC105378901, uncharacterized LOC105378901(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105378901 transcriptXR_001737801.1:n....XR_001737801.1:n.542C>GC>GNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.992C=0.008
1000GenomesAmericanSub694G=0.990C=0.010
1000GenomesEast AsianSub1008G=0.867C=0.133
1000GenomesEuropeSub1006G=0.987C=0.013
1000GenomesGlobalStudy-wide5008G=0.952C=0.048
1000GenomesSouth AsianSub978G=0.920C=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.986C=0.014
The Genome Aggregation DatabaseAfricanSub8722G=0.989C=0.011
The Genome Aggregation DatabaseAmericanSub836G=0.980C=0.020
The Genome Aggregation DatabaseEast AsianSub1620G=0.883C=0.117
The Genome Aggregation DatabaseEuropeSub18494G=0.990C=0.009
The Genome Aggregation DatabaseGlobalStudy-wide29974G=0.983C=0.016
The Genome Aggregation DatabaseOtherSub302G=0.970C=0.030
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.978C=0.021
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.990C=0.010
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs414534520.000309alcohol dependence21314694

eQTL of rs41453452 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs41453452 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1111299150111299424E0674100
chr1111255744111255892E068-39158
chr1111269454111269647E068-25403
chr1111269905111270318E068-24732
chr1111276874111277170E068-17880
chr1111299150111299424E0684100
chr1111308623111308744E06813573
chr1111308755111308976E06813705
chr1111308977111309095E06813927
chr1111255744111255892E069-39158
chr1111257457111257559E069-37491
chr1111293087111293549E069-1501
chr1111299150111299424E0694100
chr1111259934111260024E070-35026
chr1111261245111261316E070-33734
chr1111269454111269647E070-25403
chr1111269905111270318E070-24732
chr1111276874111277170E070-17880
chr1111279623111279678E070-15372
chr1111279761111279821E070-15229
chr1111279824111279911E070-15139
chr1111279950111280197E070-14853
chr1111287286111287326E070-7724
chr1111292626111292771E070-2279
chr1111293087111293549E070-1501
chr1111294256111294313E070-737
chr1111303016111303320E0707966
chr1111308336111308544E07013286
chr1111308623111308744E07013573
chr1111308755111308976E07013705
chr1111319055111319095E07024005
chr1111319348111319502E07024298
chr1111319934111320047E07024884
chr1111323277111323912E07028227
chr1111249155111249676E071-45374
chr1111257457111257559E071-37491
chr1111269454111269647E071-25403
chr1111255744111255892E072-39158
chr1111257457111257559E072-37491
chr1111292626111292771E072-2279
chr1111257457111257559E073-37491
chr1111255744111255892E074-39158
chr1111269905111270318E074-24732
chr1111299150111299424E0744100
chr1111257457111257559E081-37491
chr1111261245111261316E081-33734
chr1111269454111269647E081-25403
chr1111269905111270318E081-24732
chr1111276874111277170E081-17880
chr1111292626111292771E081-2279
chr1111293087111293549E081-1501
chr1111294256111294313E081-737
chr1111308623111308744E08113573
chr1111319055111319095E08124005
chr1111323277111323912E08128227
chr1111269905111270318E082-24732
chr1111276874111277170E082-17880
chr1111292626111292771E082-2279
chr1111293087111293549E082-1501
chr1111294256111294313E082-737