rs424508

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0126 (3780/29978,GnomAD)
T==0143 (4165/29118,TOPMED)
T==0184 (920/5008,1000G)
T==0049 (190/3854,ALSPAC)
T==0045 (167/3708,TWINSUK)
chr17:9749551 (GRCh38.p7) (17p13.1)
AD
GWASdb2
1   publication(s)
See rs on genome
27 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.9749551T>C
GRCh37.p13 chr 17NC_000017.10:g.9652868T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.287C=0.713
1000GenomesAmericanSub694T=0.100C=0.900
1000GenomesEast AsianSub1008T=0.288C=0.712
1000GenomesEuropeSub1006T=0.058C=0.942
1000GenomesGlobalStudy-wide5008T=0.184C=0.816
1000GenomesSouth AsianSub978T=0.130C=0.870
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.049C=0.951
The Genome Aggregation DatabaseAfricanSub8722T=0.242C=0.758
The Genome Aggregation DatabaseAmericanSub838T=0.100C=0.900
The Genome Aggregation DatabaseEast AsianSub1616T=0.329C=0.671
The Genome Aggregation DatabaseEuropeSub18500T=0.056C=0.943
The Genome Aggregation DatabaseGlobalStudy-wide29978T=0.126C=0.873
The Genome Aggregation DatabaseOtherSub302T=0.050C=0.950
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.143C=0.857
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.045C=0.955
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs4245080.000877alcohol dependence21314694

eQTL of rs424508 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs424508 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1796288849628968E067-23900
chr1796289699629215E067-23653
chr1796295399629686E067-23182
chr1796289699629215E068-23653
chr1796295399629686E068-23182
chr1796288849628968E069-23900
chr1796289699629215E069-23653
chr1796288849628968E070-23900
chr1796289699629215E070-23653
chr1796288849628968E071-23900
chr1796289699629215E071-23653
chr1796295399629686E071-23182
chr1796299509630072E071-22796
chr1796288849628968E072-23900
chr1796289699629215E072-23653
chr1796288849628968E073-23900
chr1796289699629215E073-23653
chr1796295399629686E073-23182
chr1796288849628968E074-23900
chr1796289699629215E074-23653
chr1796295399629686E074-23182
chr1796288849628968E081-23900
chr1796795939679665E08126725
chr1796800849680134E08127216
chr1796801429680836E08127274
chr1796957469695812E08142878
chr1796958999696033E08143031