rs4269167

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0479 (14327/29912,GnomAD)
C=0467 (13615/29118,TOPMED)
T==0443 (2218/5008,1000G)
T==0399 (1539/3854,ALSPAC)
T==0425 (1576/3708,TWINSUK)
chr4:26024134 (GRCh38.p7) (4p15.2)
AD
GWASdb2
1   publication(s)
See rs on genome
88 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.26024134T>C
GRCh37.p13 chr 4NC_000004.11:g.26025756T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.829C=0.171
1000GenomesAmericanSub694T=0.300C=0.700
1000GenomesEast AsianSub1008T=0.144C=0.856
1000GenomesEuropeSub1006T=0.414C=0.586
1000GenomesGlobalStudy-wide5008T=0.443C=0.557
1000GenomesSouth AsianSub978T=0.360C=0.640
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.399C=0.601
The Genome Aggregation DatabaseAfricanSub8698T=0.741C=0.259
The Genome Aggregation DatabaseAmericanSub834T=0.260C=0.740
The Genome Aggregation DatabaseEast AsianSub1618T=0.129C=0.871
The Genome Aggregation DatabaseEuropeSub18460T=0.397C=0.602
The Genome Aggregation DatabaseGlobalStudy-wide29912T=0.479C=0.521
The Genome Aggregation DatabaseOtherSub302T=0.400C=0.600
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.532C=0.467
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.425C=0.575
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs42691675.1E-05alcohol dependence24277619

eQTL of rs4269167 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4269167 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr42598830825988376E067-37380
chr42598843725988849E067-36907
chr42598936225989473E067-36283
chr42598947825989526E067-36230
chr42598958125990218E067-35538
chr42599307925993143E067-32613
chr42598830825988376E068-37380
chr42598843725988849E068-36907
chr42598936225989473E068-36283
chr42598947825989526E068-36230
chr42598958125990218E068-35538
chr42599307925993143E068-32613
chr42599471625995861E068-29895
chr42602340126025133E068-623
chr42602513426025273E068-483
chr42602536326025430E068-326
chr42598830825988376E069-37380
chr42598843725988849E069-36907
chr42598936225989473E069-36283
chr42598947825989526E069-36230
chr42598958125990218E069-35538
chr42599307925993143E069-32613
chr42599471625995861E069-29895
chr42602340126025133E069-623
chr42606021626060566E06934460
chr42598830825988376E070-37380
chr42598843725988849E070-36907
chr42598936225989473E070-36283
chr42598947825989526E070-36230
chr42598958125990218E070-35538
chr42599363825993787E070-31969
chr42599471625995861E070-29895
chr42604108226041318E07015326
chr42604133526041524E07015579
chr42604160826041927E07015852
chr42605189726051959E07026141
chr42605198626052097E07026230
chr42605214626052247E07026390
chr42605763326057730E07031877
chr42606021626060566E07034460
chr42606874026068967E07042984
chr42598830825988376E071-37380
chr42598843725988849E071-36907
chr42598936225989473E071-36283
chr42598947825989526E071-36230
chr42598958125990218E071-35538
chr42599307925993143E071-32613
chr42601669826017601E071-8155
chr42602340126025133E071-623
chr42606021626060566E07134460
chr42598936225989473E072-36283
chr42598947825989526E072-36230
chr42598958125990218E072-35538
chr42599307925993143E072-32613
chr42602340126025133E072-623
chr42598830825988376E073-37380
chr42598843725988849E073-36907
chr42598947825989526E073-36230
chr42598958125990218E073-35538
chr42598843725988849E074-36907
chr42598947825989526E074-36230
chr42598958125990218E074-35538
chr42599307925993143E074-32613
chr42602340126025133E074-623
chr42598830825988376E081-37380
chr42598843725988849E081-36907
chr42598936225989473E081-36283
chr42598947825989526E081-36230
chr42598958125990218E081-35538
chr42601225126012311E081-13445
chr42601399826014422E081-11334
chr42601504726015175E081-10581
chr42601548726015718E081-10038
chr42603327326033323E0817517
chr42603340526033609E0817649
chr42603362526034986E0817869
chr42604981126051210E08124055
chr42606021626060566E08134460
chr42606086826060959E08135112
chr42606106526061185E08135309
chr42598830825988376E082-37380
chr42598936225989473E082-36283
chr42598947825989526E082-36230
chr42598958125990218E082-35538
chr42601399826014422E082-11334
chr42606021626060566E08234460
chr42606086826060959E08235112
chr42606106526061185E08235309