rs4301139

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
T==0457 (13656/29866,GnomAD)
T==0460 (13413/29118,TOPMED)
T==0449 (2248/5008,1000G)
T==0490 (1890/3854,ALSPAC)
G=0499 (1849/3708,TWINSUK)
chr4:35522896 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35522896T>G
GRCh37.p13 chr 4NC_000004.11:g.35524518T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.401G=0.599
1000GenomesAmericanSub694T=0.530G=0.470
1000GenomesEast AsianSub1008T=0.296G=0.704
1000GenomesEuropeSub1006T=0.465G=0.535
1000GenomesGlobalStudy-wide5008T=0.449G=0.551
1000GenomesSouth AsianSub978T=0.600G=0.400
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.490G=0.510
The Genome Aggregation DatabaseAfricanSub8710T=0.412G=0.588
The Genome Aggregation DatabaseAmericanSub838T=0.570G=0.430
The Genome Aggregation DatabaseEast AsianSub1602T=0.258G=0.742
The Genome Aggregation DatabaseEuropeSub18414T=0.491G=0.508
The Genome Aggregation DatabaseGlobalStudy-wide29866T=0.457G=0.542
The Genome Aggregation DatabaseOtherSub302T=0.420G=0.580
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.460G=0.539
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.501G=0.499
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs43011390.000492nicotine dependence17158188

eQTL of rs4301139 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4301139 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E0742219
chr43553670135536912E08212183
chr43553699835537160E08212480


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E0682354
chr43552703435527236E0682516
chr43552753335527608E0683015
chr43552687235526986E0692354
chr43552703435527236E0692516
chr43552687235526986E0712354
chr43552703435527236E0712516
chr43552753335527608E0713015
chr43552687235526986E0722354
chr43552703435527236E0722516
chr43552687235526986E0732354
chr43552703435527236E0732516
chr43552687235526986E0742354
chr43552703435527236E0742516