rs433303

Homo sapiens
C>G / C>T
HRH1 : Intron Variant
LOC102723663 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0305 (9140/29948,GnomAD)
T=0252 (7354/29118,TOPMED)
T=0220 (1102/5008,1000G)
T=0419 (1614/3854,ALSPAC)
T=0403 (1495/3708,TWINSUK)
chr3:11203220 (GRCh38.p7) (3p25.3)
AD
GWASdb2
2   publication(s)
See rs on genome
3 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.11203220C>G
GRCh38.p7 chr 3NC_000003.12:g.11203220C>T
GRCh37.p13 chr 3NC_000003.11:g.11244906C>G
GRCh37.p13 chr 3NC_000003.11:g.11244906C>T

Gene: HRH1, histamine receptor H1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
HRH1 transcript variant 2NM_001098212.1:c.N/AIntron Variant
HRH1 transcript variant 1NM_001098213.1:c.N/AIntron Variant
HRH1 transcript variant 4NM_000861.3:c.N/AGenic Upstream Transcript Variant
HRH1 transcript variant 3NM_001098211.1:c.N/AGenic Upstream Transcript Variant
HRH1 transcript variant X3XM_011533653.2:c.N/AIntron Variant
HRH1 transcript variant X4XM_017006284.1:c.N/AIntron Variant
HRH1 transcript variant X1XM_011533652.1:c.N/AGenic Upstream Transcript Variant
HRH1 transcript variant X2XM_017006283.1:c.N/AGenic Upstream Transcript Variant

Gene: LOC102723663, uncharacterized LOC102723663(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC102723663 transcript variant X1XR_001740595.1:n.N/AIntron Variant
LOC102723663 transcript variant X2XR_001740596.1:n.N/AIntron Variant
LOC102723663 transcript variant X3XR_001740597.1:n.N/AIntron Variant
LOC102723663 transcript variant X4XR_001740598.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.943T=0.057
1000GenomesAmericanSub694C=0.770T=0.230
1000GenomesEast AsianSub1008C=0.666T=0.334
1000GenomesEuropeSub1006C=0.611T=0.389
1000GenomesGlobalStudy-wide5008C=0.780T=0.220
1000GenomesSouth AsianSub978C=0.860T=0.140
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.581T=0.419
The Genome Aggregation DatabaseAfricanSub8720C=0.893T=0.107
The Genome Aggregation DatabaseAmericanSub838C=0.750T=0.25,
The Genome Aggregation DatabaseEast AsianSub1618C=0.701T=0.299
The Genome Aggregation DatabaseEuropeSub18470C=0.597T=0.402
The Genome Aggregation DatabaseGlobalStudy-wide29948C=0.694T=0.305
The Genome Aggregation DatabaseOtherSub302C=0.760T=0.24,
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.747T=0.252
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.597T=0.403
PMID Title Author Journal
20202923A genome-wide association study of alcohol dependence.Bierut LJProc Natl Acad Sci U S A
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs4333030.00000172alcohol dependence20202923
rs4333030.00069alcohol dependence21956439

eQTL of rs433303 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs433303 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr39904354299044034E070-9019
chr39904437099044446E070-8607
chr39904354299044034E074-9019