rs433780

Homo sapiens
C>T
LOC105370263 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0192 (5752/29844,GnomAD)
C==0162 (4738/29118,TOPMED)
C==0164 (821/5008,1000G)
C==0210 (809/3854,ALSPAC)
C==0202 (749/3708,TWINSUK)
chr13:76490896 (GRCh38.p7) (13q22.2)
AD
GWASdb2
1   publication(s)
See rs on genome
12 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 13NC_000013.11:g.76490896C>T
GRCh37.p13 chr 13NC_000013.10:g.77065032C>T

Gene: LOC105370263, uncharacterized LOC105370263(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105370263 transcriptXR_001749919.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.147T=0.853
1000GenomesAmericanSub694C=0.140T=0.860
1000GenomesEast AsianSub1008C=0.162T=0.838
1000GenomesEuropeSub1006C=0.187T=0.813
1000GenomesGlobalStudy-wide5008C=0.164T=0.836
1000GenomesSouth AsianSub978C=0.190T=0.810
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.210T=0.790
The Genome Aggregation DatabaseAfricanSub8682C=0.158T=0.842
The Genome Aggregation DatabaseAmericanSub836C=0.150T=0.850
The Genome Aggregation DatabaseEast AsianSub1582C=0.169T=0.831
The Genome Aggregation DatabaseEuropeSub18444C=0.213T=0.786
The Genome Aggregation DatabaseGlobalStudy-wide29844C=0.192T=0.807
The Genome Aggregation DatabaseOtherSub300C=0.160T=0.840
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.162T=0.837
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.202T=0.798
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs4337800.000836alcohol dependence20201924

eQTL of rs433780 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs433780 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr137703563377035707E070-29325
chr137703575677035906E070-29126
chr137703700777037124E070-27908
chr137703716077037257E070-27775
chr137703756377037772E070-27260
chr137703597077036494E071-28538
chr137702965377030049E081-34983
chr137703011677030550E081-34482
chr137707405177074810E0819019
chr137707514677075255E08110114
chr137707375177073946E0828719
chr137707638077076703E08211348