rs4349619

Homo sapiens
T>A
None
Check p-value
SNV (Single Nucleotide Variation)
T==0457 (13664/29898,GnomAD)
T==0460 (13412/29118,TOPMED)
T==0449 (2249/5008,1000G)
T==0490 (1890/3854,ALSPAC)
T==0500 (1853/3708,TWINSUK)
chr4:35522461 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35522461T>A
GRCh37.p13 chr 4NC_000004.11:g.35524083T>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.401A=0.599
1000GenomesAmericanSub694T=0.530A=0.470
1000GenomesEast AsianSub1008T=0.297A=0.703
1000GenomesEuropeSub1006T=0.465A=0.535
1000GenomesGlobalStudy-wide5008T=0.449A=0.551
1000GenomesSouth AsianSub978T=0.600A=0.400
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.490A=0.510
The Genome Aggregation DatabaseAfricanSub8714T=0.412A=0.588
The Genome Aggregation DatabaseAmericanSub836T=0.570A=0.430
The Genome Aggregation DatabaseEast AsianSub1614T=0.259A=0.741
The Genome Aggregation DatabaseEuropeSub18432T=0.491A=0.508
The Genome Aggregation DatabaseGlobalStudy-wide29898T=0.457A=0.543
The Genome Aggregation DatabaseOtherSub302T=0.420A=0.580
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.460A=0.539
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.500A=0.500
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs43496190.000306nicotine dependence17158188

eQTL of rs4349619 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4349619 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E0742654
chr43553670135536912E08212618
chr43553699835537160E08212915


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E0682789
chr43552703435527236E0682951
chr43552753335527608E0683450
chr43552687235526986E0692789
chr43552703435527236E0692951
chr43552687235526986E0712789
chr43552703435527236E0712951
chr43552753335527608E0713450
chr43552687235526986E0722789
chr43552703435527236E0722951
chr43552687235526986E0732789
chr43552703435527236E0732951
chr43552687235526986E0742789
chr43552703435527236E0742951