rs4365877

Homo sapiens
G>A
FER : 3 Prime UTR Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0484 (14340/29588,GnomAD)
G==0483 (14090/29118,TOPMED)
A=0490 (2452/5008,1000G)
G==0436 (1681/3854,ALSPAC)
G==0448 (1663/3708,TWINSUK)
chr5:109188915 (GRCh38.p7) (5q21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
4 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.109188915G>A
GRCh37.p13 chr 5NC_000005.9:g.108524616G>A
FER RefSeqGeneNG_011445.2:g.446094G>A

Gene: FER, FER tyrosine kinase(plus strand)

Molecule type Change Amino acid[Codon] SO Term
FER transcript variant 1NM_005246.3:c.N/A3 Prime UTR Variant
FER transcript variant 2NM_001308028.1:c.N/A3 Prime UTR Variant
FER transcript variant 3NM_001308031.1:c.N/A3 Prime UTR Variant
FER transcript variant 4NM_001308038.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X16XM_011543276.2:c.N/A3 Prime UTR Variant
FER transcript variant X1XM_011543266.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X2XM_011543267.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X5XM_011543269.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X4XM_011543270.2:c.N/AGenic Downstream Transcript Variant
FER transcript variant X6XM_011543271.2:c.N/AGenic Downstream Transcript Variant
FER transcript variant X10XM_011543272.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X18XM_011543278.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X3XM_017009229.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X7XM_017009230.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X8XM_017009231.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X9XM_017009232.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X11XM_017009233.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X13XM_017009234.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X15XM_017009235.1:c.N/AGenic Downstream Transcript Variant
FER transcript variant X14XR_001742041.1:n.N/AGenic Downstream Transcript Variant
FER transcript variant X17XR_001742042.1:n.N/AGenic Downstream Transcript Variant
FER transcript variant X12XR_948244.2:n.N/AGenic Downstream Transcript Variant
FER transcript variant X18XR_948245.2:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.535A=0.465
1000GenomesAmericanSub694G=0.450A=0.550
1000GenomesEast AsianSub1008G=0.600A=0.400
1000GenomesEuropeSub1006G=0.450A=0.550
1000GenomesGlobalStudy-wide5008G=0.510A=0.490
1000GenomesSouth AsianSub978G=0.490A=0.510
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.436A=0.564
The Genome Aggregation DatabaseAfricanSub8602G=0.508A=0.492
The Genome Aggregation DatabaseAmericanSub832G=0.450A=0.550
The Genome Aggregation DatabaseEast AsianSub1606G=0.626A=0.374
The Genome Aggregation DatabaseEuropeSub18252G=0.462A=0.537
The Genome Aggregation DatabaseGlobalStudy-wide29588G=0.484A=0.515
The Genome Aggregation DatabaseOtherSub296G=0.510A=0.490
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.483A=0.516
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.448A=0.552
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs43658770.000685alcohol dependence20201924

eQTL of rs4365877 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4365877 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5108524738108524854E081122
chr5108535099108535271E08110483
chr5108561810108562296E08137194
chr5108561810108562296E08237194