rs4427464

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
T==0244 (6400/26228,GnomAD)
T==0248 (1242/5008,1000G)
T==0251 (967/3854,ALSPAC)
T==0239 (885/3708,TWINSUK)
chr10:63828177 (GRCh38.p7) (10q21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
6 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.63828177T>G
GRCh37.p13 chr 10NC_000010.10:g.65587937T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.273G=0.727
1000GenomesAmericanSub694T=0.210G=0.790
1000GenomesEast AsianSub1008T=0.185G=0.815
1000GenomesEuropeSub1006T=0.227G=0.773
1000GenomesGlobalStudy-wide5008T=0.248G=0.752
1000GenomesSouth AsianSub978T=0.330G=0.670
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.251G=0.749
The Genome Aggregation DatabaseAfricanSub7978T=0.299G=0.701
The Genome Aggregation DatabaseAmericanSub592T=0.200G=0.800
The Genome Aggregation DatabaseEast AsianSub1500T=0.190G=0.810
The Genome Aggregation DatabaseEuropeSub15876T=0.224G=0.776
The Genome Aggregation DatabaseGlobalStudy-wide26228T=0.244G=0.756
The Genome Aggregation DatabaseOtherSub282T=0.200G=0.800
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.239G=0.761
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs44274640.000628alcohol dependence24277619

eQTL of rs4427464 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4427464 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr106562563765627021E06937700
chr106562563765627021E07337700
chr106555941465559549E074-28388
chr106562563765627021E07437700
chr106562563765627021E08137700
chr106563100065631458E08243063