SNP Detail Info-rs4440177

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0445 (13325/29890,GnomAD)
G==0479 (13954/29118,TOPMED)
A=0494 (2475/5008,1000G)
A=0333 (1282/3854,ALSPAC)
A=0334 (1239/3708,TWINSUK)

Position: chr4:162321901 (GRCh38.p7) (4q32.2)

Phenotype: ND | AD

Dataset:

GWASdb2 | GWASCatalog

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 4 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 4	NC_000004.12:g.162321901G>A
GRCh37.p13 chr 4	NC_000004.11:g.163243053G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.267	A=0.733
1000Genomes	American	Sub	694	G=0.580	A=0.420
1000Genomes	East Asian	Sub	1008	G=0.558	A=0.442
1000Genomes	Europe	Sub	1006	G=0.654	A=0.346
1000Genomes	Global	Study-wide	5008	G=0.506	A=0.494
1000Genomes	South Asian	Sub	978	G=0.570	A=0.430
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.667	A=0.333
The Genome Aggregation Database	African	Sub	8718	G=0.313	A=0.687
The Genome Aggregation Database	American	Sub	834	G=0.540	A=0.460
The Genome Aggregation Database	East Asian	Sub	1606	G=0.567	A=0.433
The Genome Aggregation Database	Europe	Sub	18430	G=0.669	A=0.330
The Genome Aggregation Database	Global	Study-wide	29890	G=0.554	A=0.445
The Genome Aggregation Database	Other	Sub	302	G=0.460	A=0.540
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.479	A=0.520
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.666	A=0.334

PMID	Title	Author	Journal
23942779	A genome-wide association study of behavioral disinhibition.	McGue M	Behav Genet

SNP ID	p-value	Traits	Study
rs4440177	0.000006	alcohol dependence	23942779
rs4440177	0.00041	nicotine use	23942779
rs4440177	0.00066	alcohol consumption	23942779

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr4	163274008	163274115	E067	30955
chr4	163274008	163274115	E069	30955
chr4	163274008	163274115	E074	30955
chr4	163269035	163269270	E081	25982

rs4440177