rs4446619

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0387 (11611/29946,GnomAD)
A=0363 (10595/29118,TOPMED)
A=0392 (1963/5008,1000G)
A=0357 (1376/3854,ALSPAC)
A=0340 (1260/3708,TWINSUK)
chr7:156249549 (GRCh38.p7) (7q36.3)
AD
GWASdb2
1   publication(s)
See rs on genome
24 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.156249549G>A
GRCh37.p13 chr 7NC_000007.13:g.156042243G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.546A=0.454
1000GenomesAmericanSub694G=0.660A=0.340
1000GenomesEast AsianSub1008G=0.585A=0.415
1000GenomesEuropeSub1006G=0.661A=0.339
1000GenomesGlobalStudy-wide5008G=0.608A=0.392
1000GenomesSouth AsianSub978G=0.620A=0.380
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.643A=0.357
The Genome Aggregation DatabaseAfricanSub8718G=0.562A=0.438
The Genome Aggregation DatabaseAmericanSub838G=0.620A=0.380
The Genome Aggregation DatabaseEast AsianSub1620G=0.587A=0.413
The Genome Aggregation DatabaseEuropeSub18470G=0.636A=0.363
The Genome Aggregation DatabaseGlobalStudy-wide29946G=0.612A=0.387
The Genome Aggregation DatabaseOtherSub300G=0.670A=0.330
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.636A=0.363
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.660A=0.340
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs44466190.000763alcohol dependence24277619

eQTL of rs4446619 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4446619 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7156043704156043754E0671461
chr7156044373156044455E0672130
chr7156044550156044623E0672307
chr7156043704156043754E0691461
chr7156016730156016791E070-25452
chr7156016972156017262E070-24981
chr7156017317156017430E070-24813
chr7156017571156017647E070-24596
chr7156043704156043754E0701461
chr7156043942156044178E0701699
chr7156044373156044455E0702130
chr7156044373156044455E0712130
chr7156044550156044623E0712307
chr7156043704156043754E0721461
chr7156043942156044178E0721699
chr7156043704156043754E0731461
chr7156043942156044178E0731699
chr7156044373156044455E0732130
chr7156044550156044623E0732307
chr7156043704156043754E0741461
chr7156043942156044178E0741699
chr7156044373156044455E0742130
chr7156044550156044623E0742307
chr7156031159156031398E081-10845