rs446989

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0302 (9042/29922,GnomAD)
A=0334 (9744/29118,TOPMED)
A=0402 (2014/5008,1000G)
A=0195 (752/3854,ALSPAC)
A=0198 (735/3708,TWINSUK)
chr5:14106062 (GRCh38.p7) (5p15.2)
AD
GWASdb2
1   publication(s)
See rs on genome
178 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.14106062G>A
GRCh37.p13 chr 5NC_000005.9:g.14106171G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.483A=0.517
1000GenomesAmericanSub694G=0.730A=0.270
1000GenomesEast AsianSub1008G=0.440A=0.560
1000GenomesEuropeSub1006G=0.796A=0.204
1000GenomesGlobalStudy-wide5008G=0.598A=0.402
1000GenomesSouth AsianSub978G=0.620A=0.380
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.805A=0.195
The Genome Aggregation DatabaseAfricanSub8704G=0.543A=0.457
The Genome Aggregation DatabaseAmericanSub836G=0.740A=0.260
The Genome Aggregation DatabaseEast AsianSub1616G=0.421A=0.579
The Genome Aggregation DatabaseEuropeSub18464G=0.791A=0.208
The Genome Aggregation DatabaseGlobalStudy-wide29922G=0.697A=0.302
The Genome Aggregation DatabaseOtherSub302G=0.780A=0.220
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.665A=0.334
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.802A=0.198
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs4469899.11E-05alcohol consumption23743675

eQTL of rs446989 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs446989 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr51411852814119475E06712357
chr51411955314119624E06713382
chr51411978514119848E06713614
chr51411996414120014E06713793
chr51412005514120118E06713884
chr51414673814146782E06740567
chr51414684814147167E06740677
chr51414735514147639E06741184
chr51414764514147695E06741474
chr51414851814148600E06742347
chr51414883814148892E06742667
chr51414908014149264E06742909
chr51414926814149553E06743097
chr51414981414149949E06743643
chr51414998814150328E06743817
chr51415330614153505E06747135
chr51415372114153848E06747550
chr51415397214154781E06747801
chr51415484014154988E06748669
chr51415525614155489E06749085
chr51415586014156047E06749689
chr51411852814119475E06812357
chr51414226514142341E06836094
chr51414673814146782E06840567
chr51414684814147167E06840677
chr51414735514147639E06841184
chr51414764514147695E06841474
chr51414851814148600E06842347
chr51414883814148892E06842667
chr51414908014149264E06842909
chr51414926814149553E06843097
chr51414981414149949E06843643
chr51414998814150328E06843817
chr51415330614153505E06847135
chr51415372114153848E06847550
chr51415397214154781E06847801
chr51415484014154988E06848669
chr51415525614155489E06849085
chr51415586014156047E06849689
chr51411852814119475E06912357
chr51411955314119624E06913382
chr51411978514119848E06913614
chr51411996414120014E06913793
chr51412005514120118E06913884
chr51412025514120315E06914084
chr51412044514120597E06914274
chr51414673814146782E06940567
chr51414684814147167E06940677
chr51414735514147639E06941184
chr51414764514147695E06941474
chr51414851814148600E06942347
chr51414883814148892E06942667
chr51414908014149264E06942909
chr51414926814149553E06943097
chr51414981414149949E06943643
chr51414998814150328E06943817
chr51415330614153505E06947135
chr51415372114153848E06947550
chr51415397214154781E06947801
chr51411852814119475E07012357
chr51411955314119624E07013382
chr51411978514119848E07013614
chr51411996414120014E07013793
chr51412005514120118E07013884
chr51412025514120315E07014084
chr51412044514120597E07014274
chr51414684814147167E07040677
chr51414735514147639E07041184
chr51414764514147695E07041474
chr51414883814148892E07042667
chr51414908014149264E07042909
chr51414926814149553E07043097
chr51414981414149949E07043643
chr51414998814150328E07043817
chr51415330614153505E07047135
chr51415372114153848E07047550
chr51415397214154781E07047801
chr51415484014154988E07048669
chr51415525614155489E07049085
chr51410863914109019E0712468
chr51411852814119475E07112357
chr51411955314119624E07113382
chr51411978514119848E07113614
chr51411996414120014E07113793
chr51414226514142341E07136094
chr51414673814146782E07140567
chr51414684814147167E07140677
chr51414851814148600E07142347
chr51414883814148892E07142667
chr51414908014149264E07142909
chr51414926814149553E07143097
chr51414981414149949E07143643
chr51414998814150328E07143817
chr51415330614153505E07147135
chr51415372114153848E07147550
chr51415397214154781E07147801
chr51415484014154988E07148669
chr51415525614155489E07149085
chr51411852814119475E07212357
chr51411978514119848E07213614
chr51411996414120014E07213793
chr51412005514120118E07213884
chr51412025514120315E07214084
chr51412044514120597E07214274
chr51414226514142341E07236094
chr51414673814146782E07240567
chr51414684814147167E07240677
chr51414851814148600E07242347
chr51414883814148892E07242667
chr51414908014149264E07242909
chr51414926814149553E07243097
chr51414981414149949E07243643
chr51414998814150328E07243817
chr51415330614153505E07247135
chr51415484014154988E07248669
chr51411852814119475E07312357
chr51411955314119624E07313382
chr51411978514119848E07313614
chr51414735514147639E07341184
chr51414764514147695E07341474
chr51414908014149264E07342909
chr51414926814149553E07343097
chr51414981414149949E07343643
chr51414998814150328E07343817
chr51415330614153505E07347135
chr51415372114153848E07347550
chr51415397214154781E07347801
chr51415484014154988E07348669
chr51415586014156047E07349689
chr51411852814119475E07412357
chr51411955314119624E07413382
chr51411978514119848E07413614
chr51411996414120014E07413793
chr51412005514120118E07413884
chr51412025514120315E07414084
chr51414735514147639E07441184
chr51414764514147695E07441474
chr51414851814148600E07442347
chr51414883814148892E07442667
chr51414908014149264E07442909
chr51414926814149553E07443097
chr51414981414149949E07443643
chr51414998814150328E07443817
chr51415330614153505E07447135
chr51415372114153848E07447550
chr51415397214154781E07447801
chr51415484014154988E07448669
chr51415525614155489E07449085
chr51414202314142110E08135852
chr51414226514142341E08136094
chr51414673814146782E08140567
chr51414684814147167E08140677
chr51414735514147639E08141184
chr51414764514147695E08141474
chr51414851814148600E08142347
chr51414883814148892E08142667
chr51414908014149264E08142909
chr51414926814149553E08143097
chr51414981414149949E08143643
chr51414998814150328E08143817
chr51415156214151809E08145391
chr51415189314151943E08145722
chr51415330614153505E08147135
chr51415372114153848E08147550
chr51415397214154781E08147801
chr51415586014156047E08149689
chr51411852814119475E08212357
chr51411955314119624E08213382
chr51411978514119848E08213614
chr51414883814148892E08242667
chr51414908014149264E08242909
chr51414926814149553E08243097
chr51414981414149949E08243643
chr51414998814150328E08243817
chr51415330614153505E08247135
chr51415372114153848E08247550
chr51415397214154781E08247801
chr51415586014156047E08249689










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr51414252714146325E06736356
chr51414252714146325E06836356
chr51414252714146325E06936356
chr51414252714146325E07036356
chr51414252714146325E07136356
chr51414252714146325E07236356
chr51414252714146325E07336356
chr51414252714146325E07436356
chr51414252714146325E08236356