rs4477975

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0232 (6948/29946,GnomAD)
G=0239 (6974/29118,TOPMED)
G=0290 (1454/5008,1000G)
G=0162 (624/3854,ALSPAC)
G=0189 (699/3708,TWINSUK)
chr2:136251436 (GRCh38.p7) (2q22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.136251436A>G
GRCh37.p13 chr 2NC_000002.11:g.137009006A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.759G=0.241
1000GenomesAmericanSub694A=0.760G=0.240
1000GenomesEast AsianSub1008A=0.603G=0.397
1000GenomesEuropeSub1006A=0.744G=0.256
1000GenomesGlobalStudy-wide5008A=0.710G=0.290
1000GenomesSouth AsianSub978A=0.680G=0.320
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.838G=0.162
The Genome Aggregation DatabaseAfricanSub8706A=0.755G=0.245
The Genome Aggregation DatabaseAmericanSub838A=0.680G=0.320
The Genome Aggregation DatabaseEast AsianSub1614A=0.567G=0.433
The Genome Aggregation DatabaseEuropeSub18486A=0.798G=0.201
The Genome Aggregation DatabaseGlobalStudy-wide29946A=0.768G=0.232
The Genome Aggregation DatabaseOtherSub302A=0.610G=0.390
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.760G=0.239
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.811G=0.189
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs44779759.68E-05alcohol dependence21703634

eQTL of rs4477975 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4477975 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2136977310136977791E067-31215
chr2136977924136978007E067-30999
chr2136978141136978241E067-30765
chr2136977924136978007E068-30999
chr2136978141136978241E068-30765
chr2136978416136978518E068-30488
chr2136977924136978007E069-30999
chr2136978141136978241E069-30765
chr2136995499136997317E069-11689
chr2137001646137002009E069-6997
chr2137009363137009427E069357
chr2137009448137009938E069442
chr2136964127136964692E070-44314
chr2136964741136965226E070-43780
chr2136965228136965682E070-43324
chr2136983372136984335E070-24671
chr2136984351136984606E070-24400
chr2137001646137002009E070-6997
chr2137005109137005491E070-3515
chr2137005862137006220E070-2786
chr2137035376137035455E07026370
chr2137036721137036862E07027715
chr2137038596137039731E07029590
chr2137055660137055740E07046654
chr2137057144137057418E07048138
chr2137057817137057965E07048811
chr2137058409137058528E07049403
chr2136977310136977791E071-31215
chr2136977924136978007E071-30999
chr2137009233137009311E072227
chr2137009363137009427E072357
chr2137009448137009938E072442
chr2137009448137009938E073442
chr2136977924136978007E074-30999
chr2136978141136978241E074-30765
chr2137003523137004240E074-4766
chr2137008328137008511E074-495
chr2137008559137008715E074-291
chr2137008757137008891E074-115
chr2137008906137008996E074-10
chr2137009078137009141E07472
chr2137009233137009311E074227
chr2137009363137009427E074357
chr2137009448137009938E074442
chr2137010047137010134E0741041
chr2137058409137058528E08149403
chr2137003523137004240E082-4766