rs4483718

Homo sapiens
T>A / T>G
None
Check p-value
SNV (Single Nucleotide Variation)
T==0151 (4539/29938,GnomAD)
T==0159 (4632/29118,TOPMED)
T==0199 (999/5008,1000G)
T==0066 (256/3854,ALSPAC)
T==0068 (251/3708,TWINSUK)
chr13:105998395 (GRCh38.p7) (13q33.2)
ND
GWASdb2
1   publication(s)
See rs on genome
33 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 13NC_000013.11:g.105998395T>A
GRCh38.p7 chr 13NC_000013.11:g.105998395T>G
GRCh37.p13 chr 13NC_000013.10:g.106650744T>A
GRCh37.p13 chr 13NC_000013.10:g.106650744T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.198G=0.802
1000GenomesAmericanSub694T=0.190G=0.810
1000GenomesEast AsianSub1008T=0.375G=0.625
1000GenomesEuropeSub1006T=0.088G=0.912
1000GenomesGlobalStudy-wide5008T=0.199G=0.801
1000GenomesSouth AsianSub978T=0.140G=0.860
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.066G=0.934
The Genome Aggregation DatabaseAfricanSub8710T=0.220A=0.000
The Genome Aggregation DatabaseAmericanSub836T=0.220A=0.00,
The Genome Aggregation DatabaseEast AsianSub1606T=0.458A=0.000
The Genome Aggregation DatabaseEuropeSub18486T=0.090A=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29938T=0.151A=0.000
The Genome Aggregation DatabaseOtherSub300T=0.100A=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.159G=0.840
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.068G=0.932
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs44837187.73E-06alcohol and nictotine co-dependence20158304

eQTL of rs4483718 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4483718 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr133075273030752894E068-25192
chr133075324730753344E068-24742
chr133075353630753668E068-24418
chr133074049230740665E069-37421
chr133074073130740781E069-37305
chr133074086230740971E069-37115
chr133075273030752894E069-25192
chr133075324730753344E069-24742
chr133079051030790604E06912424
chr133079066430790989E06912578
chr133081073630810819E06932650
chr133080880630808856E07030720
chr133080888530809239E07030799
chr133073953930739660E071-38426
chr133074049230740665E071-37421
chr133080880630808856E07130720
chr133080888530809239E07130799
chr133075273030752894E072-25192
chr133075324730753344E072-24742
chr133075353630753668E072-24418
chr133075372430754076E072-24010
chr133077938230779441E0741296
chr133080880630808856E07430720
chr133073953930739660E081-38426
chr133074463530744831E081-33255
chr133074485330744957E081-33129
chr133076053830760686E081-17400
chr133076075430760879E081-17207
chr133076126930761460E081-16626
chr133076053830760686E082-17400
chr133076075430760879E082-17207
chr133076126930761460E082-16626
chr133076176930761842E082-16244








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr133073996430740385E067-37701
chr133073996430740385E068-37701
chr133073996430740385E069-37701
chr133073996430740385E071-37701
chr133073996430740385E072-37701
chr133073996430740385E073-37701