rs4489889

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0499 (14953/29928,GnomAD)
T=0428 (12471/29118,TOPMED)
T=0307 (1535/5008,1000G)
C==0333 (1284/3854,ALSPAC)
C==0333 (1234/3708,TWINSUK)
chr13:77451851 (GRCh38.p7) (13q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
64 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 13NC_000013.11:g.77451851C>T
GRCh37.p13 chr 13NC_000013.10:g.78025986C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.833T=0.167
1000GenomesAmericanSub694C=0.610T=0.390
1000GenomesEast AsianSub1008C=0.944T=0.056
1000GenomesEuropeSub1006C=0.360T=0.640
1000GenomesGlobalStudy-wide5008C=0.693T=0.307
1000GenomesSouth AsianSub978C=0.650T=0.350
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.333T=0.667
The Genome Aggregation DatabaseAfricanSub8714C=0.776T=0.224
The Genome Aggregation DatabaseAmericanSub834C=0.650T=0.350
The Genome Aggregation DatabaseEast AsianSub1622C=0.946T=0.054
The Genome Aggregation DatabaseEuropeSub18460C=0.325T=0.674
The Genome Aggregation DatabaseGlobalStudy-wide29928C=0.499T=0.500
The Genome Aggregation DatabaseOtherSub298C=0.350T=0.650
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.571T=0.428
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.333T=0.667
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs44898890.00046alcohol dependence(early age of onset)20201924
rs44898890.00072alcohol dependence20201924

eQTL of rs4489889 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4489889 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr137805314678053341E06727160
chr137806709778067564E06741111
chr137805560278055695E06829616
chr137805157378051930E06925587
chr137805560278055695E06929616
chr137806709778067564E06941111
chr137805070578050910E07024719
chr137805107578051146E07025089
chr137805146478051524E07025478
chr137805336178053450E07027375
chr137805347478053625E07027488
chr137805385578053905E07027869
chr137805424178054503E07028255
chr137805451078054729E07028524
chr137805487478054946E07028888
chr137806709778067564E07041111
chr137806795078068037E07041964
chr137806808978068134E07042103
chr137806822778068277E07042241
chr137806855478068604E07042568
chr137807404078074116E07048054
chr137807441578074528E07048429
chr137803385078033975E0717864
chr137805157378051930E07125587
chr137805314678053341E07127160
chr137805336178053450E07127375
chr137805451078054729E07128524
chr137805520678055256E07129220
chr137805532078055381E07129334
chr137805146478051524E07225478
chr137805157378051930E07225587
chr137805314678053341E07427160
chr137805424178054503E07428255
chr137805451078054729E07428524
chr137805487478054946E07428888
chr137805520678055256E07429220
chr137805532078055381E07429334
chr137805560278055695E07429616
chr137806709778067564E07441111
chr137803283478032915E0816848
chr137803306378033232E0817077
chr137803350778033749E0817521
chr137803378378033833E0817797
chr137803385078033975E0817864
chr137803403678034274E0818050
chr137803983178040238E08113845
chr137804037478040493E08114388
chr137804062378041238E08114637
chr137805146478051524E08125478
chr137805314678053341E08127160
chr137805336178053450E08127375
chr137805347478053625E08127488
chr137805385578053905E08127869
chr137805424178054503E08128255
chr137805451078054729E08128524
chr137803306378033232E0827077
chr137803350778033749E0827521
chr137803378378033833E0827797
chr137803385078033975E0827864
chr137803403678034274E0828050
chr137805157378051930E08225587
chr137805314678053341E08227160
chr137805336178053450E08227375
chr137805347478053625E08227488









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr137805201578053117E06726029
chr137805201578053117E06826029
chr137805201578053117E06926029
chr137805201578053117E07026029
chr137805201578053117E07126029
chr137805201578053117E07226029
chr137805201578053117E07326029
chr137805201578053117E07426029
chr137805201578053117E08126029
chr137805201578053117E08226029