rs4498148

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0456 (13651/29882,GnomAD)
C==0460 (13419/29118,TOPMED)
C==0449 (2249/5008,1000G)
C==0490 (1890/3854,ALSPAC)
C==0500 (1854/3708,TWINSUK)
T=0500 (1854/3708,TWINSUK)
chr4:35522299 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35522299C>T
GRCh37.p13 chr 4NC_000004.11:g.35523921C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.401T=0.599
1000GenomesAmericanSub694C=0.530T=0.470
1000GenomesEast AsianSub1008C=0.297T=0.703
1000GenomesEuropeSub1006C=0.465T=0.535
1000GenomesGlobalStudy-wide5008C=0.449T=0.551
1000GenomesSouth AsianSub978C=0.600T=0.400
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.490T=0.510
The Genome Aggregation DatabaseAfricanSub8706C=0.411T=0.589
The Genome Aggregation DatabaseAmericanSub836C=0.570T=0.430
The Genome Aggregation DatabaseEast AsianSub1614C=0.259T=0.741
The Genome Aggregation DatabaseEuropeSub18424C=0.491T=0.508
The Genome Aggregation DatabaseGlobalStudy-wide29882C=0.456T=0.543
The Genome Aggregation DatabaseOtherSub302C=0.420T=0.580
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.460T=0.539
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.500T=0.500
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs44981480.000206nicotine dependence17158188

eQTL of rs4498148 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4498148 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E0742816
chr43553670135536912E08212780
chr43553699835537160E08213077


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E0682951
chr43552703435527236E0683113
chr43552753335527608E0683612
chr43552687235526986E0692951
chr43552703435527236E0693113
chr43552687235526986E0712951
chr43552703435527236E0713113
chr43552753335527608E0713612
chr43552687235526986E0722951
chr43552703435527236E0723113
chr43552687235526986E0732951
chr43552703435527236E0733113
chr43552687235526986E0742951
chr43552703435527236E0743113