rs4525524

Homo sapiens
T>C
RTN4RL1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0156 (4655/29740,GnomAD)
C=0129 (3765/29118,TOPMED)
C=0127 (635/5008,1000G)
C=0193 (742/3854,ALSPAC)
C=0194 (721/3708,TWINSUK)
chr17:1941577 (GRCh38.p7) (17p13.3)
AD
GWASdb2
1   publication(s)
See rs on genome
305 Enhancers around
3 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.1941577T>C
GRCh37.p13 chr 17NC_000017.10:g.1844871T>C

Gene: RTN4RL1, reticulon 4 receptor like 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
RTN4RL1 transcriptNM_178568.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.935C=0.065
1000GenomesAmericanSub694T=0.790C=0.210
1000GenomesEast AsianSub1008T=0.884C=0.116
1000GenomesEuropeSub1006T=0.819C=0.181
1000GenomesGlobalStudy-wide5008T=0.873C=0.127
1000GenomesSouth AsianSub978T=0.890C=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.807C=0.193
The Genome Aggregation DatabaseAfricanSub8682T=0.918C=0.082
The Genome Aggregation DatabaseAmericanSub836T=0.820C=0.180
The Genome Aggregation DatabaseEast AsianSub1606T=0.879C=0.121
The Genome Aggregation DatabaseEuropeSub18318T=0.805C=0.194
The Genome Aggregation DatabaseGlobalStudy-wide29740T=0.843C=0.156
The Genome Aggregation DatabaseOtherSub298T=0.860C=0.140
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.870C=0.129
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.806C=0.194
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs45255240.000783alcohol consumption (maxi-drinks)24277619

eQTL of rs4525524 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4525524 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1718220561822125E067-22746
chr1718221681822327E067-22544
chr1718224411822481E067-22390
chr1718225321822932E067-21939
chr1718235781823793E067-21078
chr1718323121832637E067-12234
chr1718327101832791E067-12080
chr1718329701833820E067-11051
chr1718361121836221E067-8650
chr1718364401836546E067-8325
chr1718365821836691E067-8180
chr1718367471836822E067-8049
chr1718383931838498E067-6373
chr1718440261844093E067-778
chr1718441671844248E067-623
chr1718446971844807E067-64
chr1718449541845027E06783
chr1718450641845203E067193
chr1718452071845365E067336
chr1718465931846711E0671722
chr1718467631847165E0671892
chr1718474901847540E0672619
chr1718632291863279E06718358
chr1718635291863865E06718658
chr1718639361864092E06719065
chr1718818371881911E06736966
chr1718820221882110E06737151
chr1718826891882742E06737818
chr1718827971882908E06737926
chr1718829101883192E06738039
chr1718943281894385E06749457
chr1718944321894485E06749561
chr1718220561822125E068-22746
chr1718221681822327E068-22544
chr1718235781823793E068-21078
chr1718239151823965E068-20906
chr1718329701833820E068-11051
chr1718615891861660E06816718
chr1718617521862129E06816881
chr1718098791810321E069-34550
chr1718220561822125E069-22746
chr1718221681822327E069-22544
chr1718224411822481E069-22390
chr1718225321822932E069-21939
chr1718229671823017E069-21854
chr1718233171823397E069-21474
chr1718235781823793E069-21078
chr1718329701833820E069-11051
chr1718361121836221E069-8650
chr1718364401836546E069-8325
chr1718365821836691E069-8180
chr1718383931838498E069-6373
chr1718446971844807E069-64
chr1718449541845027E06983
chr1718450641845203E069193
chr1718452071845365E069336
chr1718454421845653E069571
chr1718458371845922E069966
chr1718459301845993E0691059
chr1718465931846711E0691722
chr1718467631847165E0691892
chr1718514701851543E0696599
chr1718517311851880E0696860
chr1718617521862129E06916881
chr1718622521862397E06917381
chr1718632291863279E06918358
chr1718076321807747E070-37124
chr1718092201809288E070-35583
chr1718323121832637E070-12234
chr1718327101832791E070-12080
chr1718343131834363E070-10508
chr1718344511834546E070-10325
chr1718351251835976E070-8895
chr1718361121836221E070-8650
chr1718431441843978E070-893
chr1718440261844093E070-778
chr1718441671844248E070-623
chr1718458371845922E070966
chr1718459301845993E0701059
chr1718465931846711E0701722
chr1718467631847165E0701892
chr1718504651851418E0705594
chr1718514701851543E0706599
chr1718517311851880E0706860
chr1718691511869592E07024280
chr1718696311869767E07024760
chr1718697881869877E07024917
chr1718699971870099E07025126
chr1718702571870478E07025386
chr1718705091870940E07025638
chr1718225321822932E071-21939
chr1718229671823017E071-21854
chr1718233171823397E071-21474
chr1718323121832637E071-12234
chr1718327101832791E071-12080
chr1718329701833820E071-11051
chr1718440261844093E071-778
chr1718441671844248E071-623
chr1718446971844807E071-64
chr1718449541845027E07183
chr1718450641845203E071193
chr1718452071845365E071336
chr1718454421845653E071571
chr1718467631847165E0711892
chr1718617521862129E07116881
chr1718220561822125E072-22746
chr1718221681822327E072-22544
chr1718224411822481E072-22390
chr1718225321822932E072-21939
chr1718229671823017E072-21854
chr1718233171823397E072-21474
chr1718235781823793E072-21078
chr1718329701833820E072-11051
chr1718383931838498E072-6373
chr1718446971844807E072-64
chr1718449541845027E07283
chr1718450641845203E072193
chr1718452071845365E072336
chr1718454421845653E072571
chr1718458371845922E072966
chr1718459301845993E0721059
chr1718465931846711E0721722
chr1718467631847165E0721892
chr1718617521862129E07216881
chr1718622521862397E07217381
chr1718627951862845E07217924
chr1718632291863279E07218358
chr1718713711871549E07226500
chr1718820221882110E07237151
chr1718826891882742E07237818
chr1718827971882908E07237926
chr1718829101883192E07238039
chr1718155591815941E073-28930
chr1718220561822125E073-22746
chr1718221681822327E073-22544
chr1718224411822481E073-22390
chr1718225321822932E073-21939
chr1718229671823017E073-21854
chr1718233171823397E073-21474
chr1718235781823793E073-21078
chr1718323121832637E073-12234
chr1718327101832791E073-12080
chr1718329701833820E073-11051
chr1718351251835976E073-8895
chr1718361121836221E073-8650
chr1718364401836546E073-8325
chr1718365821836691E073-8180
chr1718367471836822E073-8049
chr1718454421845653E073571
chr1718458371845922E073966
chr1718459301845993E0731059
chr1718465931846711E0731722
chr1718467631847165E0731892
chr1718622521862397E07317381
chr1718627951862845E07317924
chr1718639361864092E07319065
chr1718641261864956E07319255
chr1718697881869877E07324917
chr1718699971870099E07325126
chr1718702571870478E07325386
chr1718705091870940E07325638
chr1718758471876087E07330976
chr1718943281894385E07349457
chr1718446971844807E074-64
chr1718449541845027E07483
chr1718450641845203E074193
chr1718452071845365E074336
chr1718072481807291E081-37580
chr1718073041807441E081-37430
chr1718076321807747E081-37124
chr1718092201809288E081-35583
chr1718098791810321E081-34550
chr1718127771813268E081-31603
chr1718133851813682E081-31189
chr1718137651813864E081-31007
chr1718149691815012E081-29859
chr1718154441815532E081-29339
chr1718155591815941E081-28930
chr1718192661819652E081-25219
chr1718197611819854E081-25017
chr1718200711820169E081-24702
chr1718203341820743E081-24128
chr1718220561822125E081-22746
chr1718221681822327E081-22544
chr1718224411822481E081-22390
chr1718225321822932E081-21939
chr1718229671823017E081-21854
chr1718233171823397E081-21474
chr1718235781823793E081-21078
chr1718239151823965E081-20906
chr1718257401825790E081-19081
chr1718258931825943E081-18928
chr1718297081829768E081-15103
chr1718299071830009E081-14862
chr1718323121832637E081-12234
chr1718327101832791E081-12080
chr1718329701833820E081-11051
chr1718343131834363E081-10508
chr1718344511834546E081-10325
chr1718351251835976E081-8895
chr1718361121836221E081-8650
chr1718364401836546E081-8325
chr1718365821836691E081-8180
chr1718367471836822E081-8049
chr1718373041837370E081-7501
chr1718383931838498E081-6373
chr1718392351839285E081-5586
chr1718393361839511E081-5360
chr1718431441843978E081-893
chr1718440261844093E081-778
chr1718441671844248E081-623
chr1718446971844807E081-64
chr1718449541845027E08183
chr1718450641845203E081193
chr1718452071845365E081336
chr1718454421845653E081571
chr1718458371845922E081966
chr1718459301845993E0811059
chr1718465931846711E0811722
chr1718467631847165E0811892
chr1718474901847540E0812619
chr1718501231850173E0815252
chr1718502921850342E0815421
chr1718504651851418E0815594
chr1718514701851543E0816599
chr1718517311851880E0816860
chr1718519691852019E0817098
chr1718632291863279E08118358
chr1718635291863865E08118658
chr1718639361864092E08119065
chr1718641261864956E08119255
chr1718691511869592E08124280
chr1718696311869767E08124760
chr1718697881869877E08124917
chr1718699971870099E08125126
chr1718702571870478E08125386
chr1718705091870940E08125638
chr1718738101873951E08128939
chr1718794371879578E08134566
chr1718818371881911E08136966
chr1718820221882110E08137151
chr1718829101883192E08138039
chr1718885231888735E08143652
chr1718888221888882E08143951
chr1718900121890292E08145141
chr1718904641890755E08145593
chr1718907741890901E08145903
chr1718909451890995E08146074
chr1718944321894485E08149561
chr1718076321807747E082-37124
chr1718092201809288E082-35583
chr1718098791810321E082-34550
chr1718127771813268E082-31603
chr1718133851813682E082-31189
chr1718137651813864E082-31007
chr1718154441815532E082-29339
chr1718155591815941E082-28930
chr1718200711820169E082-24702
chr1718203341820743E082-24128
chr1718220561822125E082-22746
chr1718221681822327E082-22544
chr1718224411822481E082-22390
chr1718225321822932E082-21939
chr1718229671823017E082-21854
chr1718233171823397E082-21474
chr1718235781823793E082-21078
chr1718299071830009E082-14862
chr1718308561830906E082-13965
chr1718323121832637E082-12234
chr1718327101832791E082-12080
chr1718343131834363E082-10508
chr1718344511834546E082-10325
chr1718351251835976E082-8895
chr1718361121836221E082-8650
chr1718364401836546E082-8325
chr1718365821836691E082-8180
chr1718367471836822E082-8049
chr1718373041837370E082-7501
chr1718383931838498E082-6373
chr1718392351839285E082-5586
chr1718431441843978E082-893
chr1718440261844093E082-778
chr1718441671844248E082-623
chr1718446971844807E082-64
chr1718449541845027E08283
chr1718450641845203E082193
chr1718452071845365E082336
chr1718454421845653E082571
chr1718458371845922E082966
chr1718459301845993E0821059
chr1718465931846711E0821722
chr1718502921850342E0825421
chr1718504651851418E0825594
chr1718514701851543E0826599
chr1718517311851880E0826860
chr1718519691852019E0827098
chr1718691511869592E08224280
chr1718696311869767E08224760
chr1718697881869877E08224917
chr1718699971870099E08225126
chr1718702571870478E08225386
chr1718705091870940E08225638
chr1718904641890755E08245593
chr1718907741890901E08245903
chr1718909451890995E08246074










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1718111791812671E068-32200
chr1718111791812671E070-32200
chr1718111791812671E082-32200