rs4566673

Homo sapiens
A>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0479 (14319/29860,GnomAD)
C=0495 (14439/29118,TOPMED)
C=0472 (2365/5008,1000G)
C=0491 (1891/3854,ALSPAC)
A==0499 (1850/3708,TWINSUK)
chr4:35515173 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35515173A>C
GRCh37.p13 chr 4NC_000004.11:g.35516795A>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.510C=0.490
1000GenomesAmericanSub694A=0.470C=0.530
1000GenomesEast AsianSub1008A=0.707C=0.293
1000GenomesEuropeSub1006A=0.535C=0.465
1000GenomesGlobalStudy-wide5008A=0.528C=0.472
1000GenomesSouth AsianSub978A=0.400C=0.600
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.509C=0.491
The Genome Aggregation DatabaseAfricanSub8702A=0.512C=0.488
The Genome Aggregation DatabaseAmericanSub834A=0.430C=0.570
The Genome Aggregation DatabaseEast AsianSub1614A=0.741C=0.259
The Genome Aggregation DatabaseEuropeSub18408A=0.508C=0.491
The Genome Aggregation DatabaseGlobalStudy-wide29860A=0.520C=0.479
The Genome Aggregation DatabaseOtherSub302A=0.580C=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.504C=0.495
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.499C=0.501
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs45666730.000372nicotine dependence17158188

eQTL of rs4566673 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4566673 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E0749942
chr43553670135536912E08219906
chr43553699835537160E08220203


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43546683035466880E067-49915
chr43552687235526986E06810077
chr43552703435527236E06810239
chr43552753335527608E06810738
chr43546683035466880E069-49915
chr43552687235526986E06910077
chr43552703435527236E06910239
chr43546683035466880E071-49915
chr43552687235526986E07110077
chr43552703435527236E07110239
chr43552753335527608E07110738
chr43546683035466880E072-49915
chr43552687235526986E07210077
chr43552703435527236E07210239
chr43552687235526986E07310077
chr43552703435527236E07310239
chr43552687235526986E07410077
chr43552703435527236E07410239