rs4610540

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0114 (3413/29946,GnomAD)
T==0097 (2851/29118,TOPMED)
T==0106 (531/5008,1000G)
T==0148 (569/3854,ALSPAC)
T==0130 (483/3708,TWINSUK)
chr6:66990490 (GRCh38.p7) (6q12)
AD
GWASdb2
1   publication(s)
See rs on genome
1 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.66990490T>C
GRCh37.p13 chr 6NC_000006.11:g.67700383T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.070C=0.930
1000GenomesAmericanSub694T=0.120C=0.880
1000GenomesEast AsianSub1008T=0.119C=0.881
1000GenomesEuropeSub1006T=0.108C=0.892
1000GenomesGlobalStudy-wide5008T=0.106C=0.894
1000GenomesSouth AsianSub978T=0.130C=0.870
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.148C=0.852
The Genome Aggregation DatabaseAfricanSub8724T=0.079C=0.921
The Genome Aggregation DatabaseAmericanSub836T=0.130C=0.870
The Genome Aggregation DatabaseEast AsianSub1600T=0.118C=0.882
The Genome Aggregation DatabaseEuropeSub18484T=0.129C=0.870
The Genome Aggregation DatabaseGlobalStudy-wide29946T=0.114C=0.886
The Genome Aggregation DatabaseOtherSub302T=0.120C=0.880
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.097C=0.902
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.130C=0.870
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs46105400.00092alcohol dependence(early age of onset)20201924
rs46105400.00098alcohol dependence20201924

eQTL of rs4610540 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4610540 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr66765039067650515E081-49868