rs4613591

Homo sapiens
A>C / A>T
None
Check p-value
SNV (Single Nucleotide Variation)
C=0485 (14492/29852,GnomAD)
A==0494 (14396/29118,TOPMED)
C=0479 (2398/5008,1000G)
chr4:35511728 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35511728A>C
GRCh38.p7 chr 4NC_000004.12:g.35511728A>T
GRCh37.p13 chr 4NC_000004.11:g.35513350A>C
GRCh37.p13 chr 4NC_000004.11:g.35513350A>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.489C=0.511
1000GenomesAmericanSub694A=0.460C=0.540
1000GenomesEast AsianSub1008A=0.707C=0.293
1000GenomesEuropeSub1006A=0.533C=0.467
1000GenomesGlobalStudy-wide5008A=0.521C=0.479
1000GenomesSouth AsianSub978A=0.400C=0.600
The Genome Aggregation DatabaseAfricanSub8702A=0.492C=0.508
The Genome Aggregation DatabaseAmericanSub832A=0.420C=0.580
The Genome Aggregation DatabaseEast AsianSub1602A=0.740C=0.260
The Genome Aggregation DatabaseEuropeSub18414A=0.508C=0.491
The Genome Aggregation DatabaseGlobalStudy-wide29852A=0.514C=0.485
The Genome Aggregation DatabaseOtherSub302A=0.580C=0.420
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.494C=0.505
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs46135910.000233nicotine dependence17158188

eQTL of rs4613591 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4613591 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E07411327
chr43553670135536912E08221291
chr43553699835537160E08221588


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43546683035466880E067-48530
chr43552687235526986E06811462
chr43552703435527236E06811624
chr43552753335527608E06812123
chr43546683035466880E069-48530
chr43552687235526986E06911462
chr43552703435527236E06911624
chr43546683035466880E071-48530
chr43552687235526986E07111462
chr43552703435527236E07111624
chr43552753335527608E07112123
chr43546683035466880E072-48530
chr43552687235526986E07211462
chr43552703435527236E07211624
chr43552687235526986E07311462
chr43552703435527236E07311624
chr43552687235526986E07411462
chr43552703435527236E07411624