rs4615965

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0454 (13589/29900,GnomAD)
C==0498 (14508/29118,TOPMED)
C==0492 (2464/5008,1000G)
T=0339 (1307/3854,ALSPAC)
T=0328 (1216/3708,TWINSUK)
chr10:84038824 (GRCh38.p7) (10q23.1)
AD
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
2 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.84038824C>T
GRCh37.p13 chr 10NC_000010.10:g.85798580C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.262T=0.738
1000GenomesAmericanSub694C=0.480T=0.520
1000GenomesEast AsianSub1008C=0.601T=0.399
1000GenomesEuropeSub1006C=0.670T=0.330
1000GenomesGlobalStudy-wide5008C=0.492T=0.508
1000GenomesSouth AsianSub978C=0.520T=0.480
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.661T=0.339
The Genome Aggregation DatabaseAfricanSub8696C=0.322T=0.678
The Genome Aggregation DatabaseAmericanSub838C=0.490T=0.510
The Genome Aggregation DatabaseEast AsianSub1618C=0.587T=0.413
The Genome Aggregation DatabaseEuropeSub18446C=0.650T=0.349
The Genome Aggregation DatabaseGlobalStudy-wide29900C=0.545T=0.454
The Genome Aggregation DatabaseOtherSub302C=0.480T=0.520
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.498T=0.501
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.672T=0.328
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs46159650.000086alcohol dependence20201924
rs46159650.0000865alcoholismpha002893
rs46159650.00017alcohol dependence(early age of onset)20201924

eQTL of rs4615965 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4615965 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr108575954585759629E070-38951
chr108575974285759810E070-38770
chr108576019985760257E070-38323

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr108580917085809315E06810590
chr108580917085809315E07110590