rs463877

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0141 (4232/29956,GnomAD)
T==0141 (4107/29118,TOPMED)
T==0128 (639/5008,1000G)
T==0122 (470/3854,ALSPAC)
T==0135 (500/3708,TWINSUK)
chr21:20717939 (GRCh38.p7) (21q21.1)
AD
GWASdb2
1   publication(s)
See rs on genome
46 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 21NC_000021.9:g.20717939T>C
GRCh37.p13 chr 21NC_000021.8:g.22090256T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.217C=0.783
1000GenomesAmericanSub694T=0.120C=0.880
1000GenomesEast AsianSub1008T=0.060C=0.940
1000GenomesEuropeSub1006T=0.129C=0.871
1000GenomesGlobalStudy-wide5008T=0.128C=0.872
1000GenomesSouth AsianSub978T=0.080C=0.920
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.122C=0.878
The Genome Aggregation DatabaseAfricanSub8720T=0.193C=0.807
The Genome Aggregation DatabaseAmericanSub838T=0.080C=0.920
The Genome Aggregation DatabaseEast AsianSub1620T=0.054C=0.946
The Genome Aggregation DatabaseEuropeSub18476T=0.128C=0.871
The Genome Aggregation DatabaseGlobalStudy-wide29956T=0.141C=0.858
The Genome Aggregation DatabaseOtherSub302T=0.080C=0.920
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.141C=0.859
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.135C=0.865
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs4638775.8E-05alcohol consumption23743675

eQTL of rs463877 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs463877 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr212210684322106990E06716587
chr212210842522108506E06718169
chr212210926622109361E06719010
chr212210926622109361E06819010
chr212210941722109555E06819161
chr212210976622109877E06819510
chr212210991522110206E06819659
chr212210842522108506E06918169
chr212210864922108754E06918393
chr212210926622109361E06919010
chr212210941722109555E06919161
chr212207525122075412E070-14844
chr212207585422076066E070-14190
chr212210738722107450E07017131
chr212210773222107777E07017476
chr212210792222108038E07017666
chr212210926622109361E07019010
chr212210941722109555E07019161
chr212210976622109877E07019510
chr212210991522110206E07019659
chr212211230022112353E07022044
chr212210738722107450E07117131
chr212210773222107777E07117476
chr212210792222108038E07117666
chr212210842522108506E07118169
chr212210864922108754E07118393
chr212210926622109361E07119010
chr212210976622109877E07119510
chr212210991522110206E07119659
chr212210738722107450E07217131
chr212210773222107777E07217476
chr212210792222108038E07217666
chr212210842522108506E07218169
chr212210864922108754E07218393
chr212210661422106677E07416358
chr212210684322106990E07416587
chr212210738722107450E07417131
chr212210773222107777E07417476
chr212210792222108038E07417666
chr212210842522108506E07418169
chr212210864922108754E07418393
chr212210926622109361E07419010
chr212210991522110206E07419659
chr212210941722109555E08119161
chr212210976622109877E08119510
chr212210991522110206E08119659