rs4677086

Homo sapiens
C>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0442 (13240/29934,GnomAD)
G=0391 (11386/29118,TOPMED)
G=0399 (2000/5008,1000G)
C==0476 (1835/3854,ALSPAC)
C==0479 (1775/3708,TWINSUK)
chr3:72109181 (GRCh38.p7) (3p13)
AD
GWASdb2
1   publication(s)
See rs on genome
192 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.72109181C>G
GRCh37.p13 chr 3NC_000003.11:g.72158332C>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.799G=0.201
1000GenomesAmericanSub694C=0.500G=0.500
1000GenomesEast AsianSub1008C=0.576G=0.424
1000GenomesEuropeSub1006C=0.500G=0.500
1000GenomesGlobalStudy-wide5008C=0.601G=0.399
1000GenomesSouth AsianSub978C=0.530G=0.470
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.476G=0.524
The Genome Aggregation DatabaseAfricanSub8714C=0.749G=0.251
The Genome Aggregation DatabaseAmericanSub834C=0.460G=0.540
The Genome Aggregation DatabaseEast AsianSub1618C=0.576G=0.424
The Genome Aggregation DatabaseEuropeSub18466C=0.468G=0.531
The Genome Aggregation DatabaseGlobalStudy-wide29934C=0.557G=0.442
The Genome Aggregation DatabaseOtherSub302C=0.660G=0.340
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.609G=0.391
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.479G=0.521
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs46770868.72E-05alcohol consumption23743675

eQTL of rs4677086 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4677086 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr37212063872120693E067-37639
chr37212077572120860E067-37472
chr37218752272187692E06729190
chr37219319172193241E06734859
chr37219329772193460E06734965
chr37219363272193843E06735300
chr37219393772194320E06735605
chr37219433972194517E06736007
chr37219456072195128E06736228
chr37219513072195222E06736798
chr37219525172195446E06736919
chr37220139372201527E06743061
chr37220413372204428E06745801
chr37220446772205190E06746135
chr37220614372206296E06747811
chr37220691772207061E06748585
chr37220749872207738E06749166
chr37212665772127568E068-30764
chr37212774772127804E068-30528
chr37213943572139568E068-18764
chr37219319172193241E06834859
chr37219329772193460E06834965
chr37219363272193843E06835300
chr37219393772194320E06835605
chr37219433972194517E06836007
chr37219456072195128E06836228
chr37219513072195222E06836798
chr37220139372201527E06843061
chr37220313272203331E06844800
chr37220346472203508E06845132
chr37220413372204428E06845801
chr37220446772205190E06846135
chr37220614372206296E06847811
chr37220691772207061E06848585
chr37220749872207738E06849166
chr37211448472114671E069-43661
chr37211488672115113E069-43219
chr37214823972148300E069-10032
chr37214832372148434E069-9898
chr37214851172149086E069-9246
chr37215363372153878E069-4454
chr37217817572178432E06919843
chr37219319172193241E06934859
chr37219329772193460E06934965
chr37219363272193843E06935300
chr37219393772194320E06935605
chr37219433972194517E06936007
chr37219456072195128E06936228
chr37219513072195222E06936798
chr37219525172195446E06936919
chr37219975372199826E06941421
chr37219985072199912E06941518
chr37219994672200991E06941614
chr37220139372201527E06943061
chr37220413372204428E06945801
chr37220446772205190E06946135
chr37220555972205731E06947227
chr37220614372206296E06947811
chr37220691772207061E06948585
chr37220749872207738E06949166
chr37212665772127568E070-30764
chr37212774772127804E070-30528
chr37216036472160414E0702032
chr37216049972160729E0702167
chr37218752272187692E07029190
chr37219363272193843E07035300
chr37219393772194320E07035605
chr37219433972194517E07036007
chr37219456072195128E07036228
chr37219513072195222E07036798
chr37219525172195446E07036919
chr37219569772195747E07037365
chr37219595872196015E07037626
chr37220139372201527E07043061
chr37211488672115113E071-43219
chr37211527472115506E071-42826
chr37211556072115723E071-42609
chr37212774772127804E071-30528
chr37212786172127940E071-30392
chr37212798172128178E071-30154
chr37213943572139568E071-18764
chr37213978472140143E071-18189
chr37215119272151760E071-6572
chr37215195272152006E071-6326
chr37215213372152305E071-6027
chr37215363372153878E071-4454
chr37218752272187692E07129190
chr37219048872191082E07132156
chr37219319172193241E07134859
chr37219329772193460E07134965
chr37219363272193843E07135300
chr37219393772194320E07135605
chr37219433972194517E07136007
chr37219456072195128E07136228
chr37219513072195222E07136798
chr37219975372199826E07141421
chr37219985072199912E07141518
chr37219994672200991E07141614
chr37220139372201527E07143061
chr37220313272203331E07144800
chr37220346472203508E07145132
chr37220413372204428E07145801
chr37220446772205190E07146135
chr37220555972205731E07147227
chr37220614372206296E07147811
chr37220691772207061E07148585
chr37220749872207738E07149166
chr37211448472114671E072-43661
chr37211488672115113E072-43219
chr37211527472115506E072-42826
chr37213943572139568E072-18764
chr37218752272187692E07229190
chr37219048872191082E07232156
chr37219253372192755E07234201
chr37219319172193241E07234859
chr37219329772193460E07234965
chr37219363272193843E07235300
chr37219393772194320E07235605
chr37219433972194517E07236007
chr37219456072195128E07236228
chr37219513072195222E07236798
chr37219525172195446E07236919
chr37219994672200991E07241614
chr37220139372201527E07243061
chr37220413372204428E07245801
chr37220446772205190E07246135
chr37220555972205731E07247227
chr37220614372206296E07247811
chr37220691772207061E07248585
chr37220749872207738E07249166
chr37219319172193241E07334859
chr37219329772193460E07334965
chr37219363272193843E07335300
chr37219393772194320E07335605
chr37219433972194517E07336007
chr37219456072195128E07336228
chr37219513072195222E07336798
chr37219525172195446E07336919
chr37220139372201527E07343061
chr37220413372204428E07345801
chr37220446772205190E07346135
chr37220614372206296E07347811
chr37220691772207061E07348585
chr37211448472114671E074-43661
chr37211488672115113E074-43219
chr37211527472115506E074-42826
chr37211556072115723E074-42609
chr37213943572139568E074-18764
chr37213978472140143E074-18189
chr37215363372153878E074-4454
chr37218415672184583E07425824
chr37219048872191082E07432156
chr37219127172191408E07432939
chr37219319172193241E07434859
chr37219329772193460E07434965
chr37219363272193843E07435300
chr37219393772194320E07435605
chr37219433972194517E07436007
chr37219456072195128E07436228
chr37219513072195222E07436798
chr37219525172195446E07436919
chr37219994672200991E07441614
chr37220139372201527E07443061
chr37220313272203331E07444800
chr37220346472203508E07445132
chr37220413372204428E07445801
chr37220446772205190E07446135
chr37220555972205731E07447227
chr37220614372206296E07447811
chr37220749872207738E07449166
chr37212855672128947E081-29385
chr37216036472160414E0812032
chr37216049972160729E0812167
chr37217817572178432E08119843
chr37217869272179216E08120360
chr37217936872179446E08121036
chr37218415672184583E08125824
chr37219433972194517E08136007
chr37219456072195128E08136228
chr37219513072195222E08136798
chr37219525172195446E08136919
chr37219569772195747E08137365
chr37220139372201527E08143061
chr37212665772127568E082-30764
chr37212774772127804E082-30528
chr37216036472160414E0822032
chr37216049972160729E0822167
chr37219393772194320E08235605
chr37219433972194517E08236007
chr37219456072195128E08236228
chr37219513072195222E08236798
chr37220139372201527E08243061