rs4687610

Homo sapiens
T>C
VPRBP : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0083 (2418/29118,TOPMED)
C=0148 (739/5008,1000G)
C=0019 (75/3854,ALSPAC)
C=0014 (53/3708,TWINSUK)
chr3:51449194 (GRCh38.p7) (3p21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
60 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.51449194T>C
GRCh37.p13 chr 3 fix patch HG186_PATCHNW_003315910.1:g.70517T>C
GRCh37.p13 chr 3NC_000003.11:g.51483210T>C

Gene: VPRBP, Vpr (HIV-1) binding protein(minus strand)

Molecule type Change Amino acid[Codon] SO Term
DCAF1 transcript variant 2NM_001171904.1:c.N/AIntron Variant
DCAF1 transcript variant 1NM_014703.2:c.N/AIntron Variant
VPRBP transcript variant X10XM_005276753.4:c.N/AIntron Variant
VPRBP transcript variant X9XM_005276755.4:c.N/AIntron Variant
VPRBP transcript variant X3XM_011534273.2:c.N/AIntron Variant
VPRBP transcript variant X2XM_011534274.2:c.N/AIntron Variant
VPRBP transcript variant X7XM_011534275.2:c.N/AIntron Variant
VPRBP transcript variant X6XM_011534276.2:c.N/AIntron Variant
VPRBP transcript variant X1XM_011534277.2:c.N/AIntron Variant
VPRBP transcript variant X4XM_017007546.1:c.N/AIntron Variant
VPRBP transcript variant X5XM_017007547.1:c.N/AIntron Variant
VPRBP transcript variant X8XM_017007548.1:c.N/AIntron Variant
VPRBP transcript variant X11XM_017007549.1:c.N/AIntron Variant
VPRBP transcript variant X12XM_017007550.1:c.N/AIntron Variant
VPRBP transcript variant X16XM_017007551.1:c.N/AIntron Variant
VPRBP transcript variant X13XR_001740385.1:n.N/AIntron Variant
VPRBP transcript variant X14XR_001740386.1:n.N/AIntron Variant
VPRBP transcript variant X15XR_001740387.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.885C=0.115
1000GenomesAmericanSub694T=0.760C=0.240
1000GenomesEast AsianSub1008T=0.647C=0.353
1000GenomesEuropeSub1006T=0.980C=0.020
1000GenomesGlobalStudy-wide5008T=0.852C=0.148
1000GenomesSouth AsianSub978T=0.960C=0.040
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.981C=0.019
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.917C=0.083
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.986C=0.014
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs46876100.000127alcohol dependence20201924

eQTL of rs4687610 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4687610 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3104810105451E06734293
chr3114174114280E06743657
chr3114437114799E06743920
chr3114174114280E06843657
chr3114437114799E06843920
chr3114802115003E06844285
chr3115137115254E06844620
chr3115361115440E06844844
chr3104810105451E06934293
chr3105525105633E06935008
chr3114174114280E06943657
chr3114437114799E06943920
chr3114802115003E06944285
chr3115137115254E06944620
chr3115361115440E06944844
chr3114174114280E07043657
chr3114437114799E07043920
chr3114802115003E07044285
chr3115137115254E07044620
chr3115361115440E07044844
chr3116283116363E07045766
chr3116414116901E07045897
chr3117032117204E07046515
chr3117319117416E07046802
chr3117466117544E07046949
chr3104810105451E07134293
chr3105525105633E07135008
chr3114174114280E07143657
chr3114437114799E07143920
chr3114802115003E07144285
chr3115137115254E07144620
chr3105525105633E07235008
chr3114174114280E07243657
chr3114437114799E07243920
chr3114802115003E07244285
chr3115137115254E07244620
chr3115361115440E07244844
chr3111467111643E07440950
chr3114437114799E07443920
chr3114802115003E07444285
chr3115137115254E07444620
chr3115361115440E07444844
chr38431584369E08113798
chr38610586168E08115588
chr3104810105451E08134293
chr3105525105633E08135008
chr3114437114799E08143920
chr3114802115003E08144285
chr3115137115254E08144620
chr3115361115440E08144844
chr38431584369E08213798
chr3104810105451E08234293
chr3105525105633E08235008
chr3114437114799E08243920
chr3114802115003E08244285
chr3115137115254E08244620
chr3115361115440E08244844
chr3117032117204E08246515
chr3117319117416E08246802
chr3117466117544E08246949