rs4687935

Homo sapiens
G>A
LOC105374060 : Intron Variant
LOC107983969 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0378 (11323/29904,GnomAD)
A=0404 (11787/29118,TOPMED)
A=0417 (2088/5008,1000G)
A=0396 (1528/3854,ALSPAC)
A=0399 (1479/3708,TWINSUK)
chr3:118694631 (GRCh38.p7) (3q13.32)
ND
GWASdb2
1   publication(s)
See rs on genome
15 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.118694631G>A
GRCh37.p13 chr 3NC_000003.11:g.118413478G>A

Gene: LOC105374060, uncharacterized LOC105374060(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105374060 transcriptNR_135547.1:n.N/AIntron Variant

Gene: LOC107983969, uncharacterized LOC107983969(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107983969 transcriptXR_924386.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.599A=0.401
1000GenomesAmericanSub694G=0.740A=0.260
1000GenomesEast AsianSub1008G=0.558A=0.442
1000GenomesEuropeSub1006G=0.631A=0.369
1000GenomesGlobalStudy-wide5008G=0.583A=0.417
1000GenomesSouth AsianSub978G=0.430A=0.570
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.604A=0.396
The Genome Aggregation DatabaseAfricanSub8694G=0.582A=0.418
The Genome Aggregation DatabaseAmericanSub836G=0.790A=0.210
The Genome Aggregation DatabaseEast AsianSub1616G=0.600A=0.400
The Genome Aggregation DatabaseEuropeSub18456G=0.634A=0.365
The Genome Aggregation DatabaseGlobalStudy-wide29904G=0.621A=0.378
The Genome Aggregation DatabaseOtherSub302G=0.620A=0.380
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.595A=0.404
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.601A=0.399
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs46879358.02E-05nicotine dependence (smoking)22377092

eQTL of rs4687935 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4687935 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3118424059118424143E07010581
chr3118424316118424377E07010838
chr3118424586118424807E07011108
chr3118424838118424960E07011360
chr3118411241118411743E081-1735
chr3118424059118424143E08110581
chr3118424316118424377E08110838
chr3118424586118424807E08111108
chr3118424838118424960E08111360
chr3118425351118425453E08111873
chr3118426779118427266E08113301
chr3118424059118424143E08210581
chr3118424316118424377E08210838
chr3118424586118424807E08211108
chr3118424838118424960E08211360