rs4699741

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0078 (2342/29972,GnomAD)
C=0083 (2417/29118,TOPMED)
C=0119 (596/5008,1000G)
C=0065 (249/3854,ALSPAC)
C=0070 (260/3708,TWINSUK)
chr4:99357540 (GRCh38.p7) (4q23)
AD
GWASCatalog
1   publication(s)
See rs on genome
3 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.99357540T>C
GRCh37.p13 chr 4NC_000004.11:g.100278697T>C
ADH1C RefSeqGeneNG_011718.1:g.221A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.945C=0.055
1000GenomesAmericanSub694T=0.640C=0.360
1000GenomesEast AsianSub1008T=0.841C=0.159
1000GenomesEuropeSub1006T=0.920C=0.080
1000GenomesGlobalStudy-wide5008T=0.881C=0.119
1000GenomesSouth AsianSub978T=0.960C=0.040
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.935C=0.065
The Genome Aggregation DatabaseAfricanSub8724T=0.940C=0.060
The Genome Aggregation DatabaseAmericanSub838T=0.680C=0.320
The Genome Aggregation DatabaseEast AsianSub1616T=0.821C=0.179
The Genome Aggregation DatabaseEuropeSub18492T=0.935C=0.064
The Genome Aggregation DatabaseGlobalStudy-wide29972T=0.921C=0.078
The Genome Aggregation DatabaseOtherSub302T=0.780C=0.220
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.917C=0.083
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.930C=0.070
PMID Title Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs46997416.00E-08alcohol dependence24166409
rs46997411.00E-06alcohol dependence24166409

eQTL of rs4699741 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4699741 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4100245602100245886E068-32811
chr4100244954100245162E073-33535
chr4100245344100245493E073-33204