rs4727685

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0240 (7189/29946,GnomAD)
G==0243 (7084/29118,TOPMED)
G==0174 (869/5008,1000G)
G==0296 (1139/3854,ALSPAC)
G==0297 (1103/3708,TWINSUK)
chr7:107731613 (GRCh38.p7) (7q22.3)
AD
GWASdb2
1   publication(s)
See rs on genome
86 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.107731613G>A
GRCh37.p13 chr 7NC_000007.13:g.107372058G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.189A=0.811
1000GenomesAmericanSub694G=0.230A=0.770
1000GenomesEast AsianSub1008G=0.017A=0.983
1000GenomesEuropeSub1006G=0.304A=0.696
1000GenomesGlobalStudy-wide5008G=0.174A=0.826
1000GenomesSouth AsianSub978G=0.140A=0.860
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.296A=0.704
The Genome Aggregation DatabaseAfricanSub8714G=0.209A=0.791
The Genome Aggregation DatabaseAmericanSub834G=0.170A=0.830
The Genome Aggregation DatabaseEast AsianSub1622G=0.011A=0.989
The Genome Aggregation DatabaseEuropeSub18474G=0.276A=0.723
The Genome Aggregation DatabaseGlobalStudy-wide29946G=0.240A=0.759
The Genome Aggregation DatabaseOtherSub302G=0.300A=0.700
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.243A=0.756
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.297A=0.703
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs47276856.54E-05alcohol consumption23743675

eQTL of rs4727685 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4727685 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7107333486107333578E067-38480
chr7107333824107334105E067-37953
chr7107334175107334517E067-37541
chr7107334625107335182E067-36876
chr7107335233107335327E067-36731
chr7107383023107383099E06710965
chr7107386669107386772E06714611
chr7107387624107387709E06715566
chr7107387798107387880E06715740
chr7107333486107333578E068-38480
chr7107333824107334105E068-37953
chr7107334175107334517E068-37541
chr7107334625107335182E068-36876
chr7107335233107335327E068-36731
chr7107341168107341256E068-30802
chr7107341276107341497E068-30561
chr7107382753107382818E06810695
chr7107386669107386772E06814611
chr7107387624107387709E06815566
chr7107387798107387880E06815740
chr7107387932107387978E06815874
chr7107388350107388400E06816292
chr7107333486107333578E069-38480
chr7107333824107334105E069-37953
chr7107334175107334517E069-37541
chr7107334625107335182E069-36876
chr7107335233107335327E069-36731
chr7107335529107335618E069-36440
chr7107337294107337374E069-34684
chr7107337495107337545E069-34513
chr7107383023107383099E06910965
chr7107386669107386772E06914611
chr7107387624107387709E06915566
chr7107387798107387880E06915740
chr7107387932107387978E06915874
chr7107332948107333294E070-38764
chr7107333486107333578E070-38480
chr7107333824107334105E070-37953
chr7107334175107334517E070-37541
chr7107334625107335182E070-36876
chr7107335233107335327E070-36731
chr7107335529107335618E070-36440
chr7107335644107335829E070-36229
chr7107337495107337545E070-34513
chr7107337639107338679E070-33379
chr7107383023107383099E07010965
chr7107386669107386772E07014611
chr7107387798107387880E07015740
chr7107387932107387978E07015874
chr7107388350107388400E07016292
chr7107332129107332230E071-39828
chr7107332267107332442E071-39616
chr7107332948107333294E071-38764
chr7107333486107333578E071-38480
chr7107333824107334105E071-37953
chr7107335233107335327E071-36731
chr7107337495107337545E071-34513
chr7107337639107338679E071-33379
chr7107383023107383099E07110965
chr7107333824107334105E072-37953
chr7107334175107334517E072-37541
chr7107334625107335182E072-36876
chr7107337639107338679E072-33379
chr7107383023107383099E07210965
chr7107386669107386772E07214611
chr7107333824107334105E073-37953
chr7107334175107334517E073-37541
chr7107334625107335182E073-36876
chr7107335233107335327E073-36731
chr7107337639107338679E073-33379
chr7107333486107333578E074-38480
chr7107333824107334105E074-37953
chr7107334175107334517E074-37541
chr7107335233107335327E074-36731
chr7107333824107334105E081-37953
chr7107337639107338679E081-33379
chr7107338996107339076E081-32982
chr7107334175107334517E082-37541
chr7107334625107335182E082-36876
chr7107337294107337374E082-34684
chr7107337495107337545E082-34513
chr7107337639107338679E082-33379
chr7107386669107386772E08214611
chr7107387798107387880E08215740
chr7107387932107387978E08215874
chr7107388350107388400E08216292










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr7107383118107385525E06711060
chr7107383118107385525E06811060
chr7107383118107385525E06911060
chr7107383118107385525E07011060
chr7107383118107385525E07111060
chr7107383118107385525E07211060
chr7107383118107385525E07311060
chr7107383118107385525E07411060
chr7107383118107385525E08111060
chr7107383118107385525E08211060