rs4732900

Homo sapiens
T>A / T>C
ADRA1A : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0250 (7497/29930,GnomAD)
T==0203 (5938/29118,TOPMED)
T==0143 (717/5008,1000G)
T==0326 (1255/3854,ALSPAC)
T==0340 (1262/3708,TWINSUK)
chr8:26820138 (GRCh38.p7) (8p21.2)
CD
GWASdb2
1   publication(s)
See rs on genome
14 Enhancers around
7 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.26820138T>A
GRCh38.p7 chr 8NC_000008.11:g.26820138T>C
GRCh37.p13 chr 8NC_000008.10:g.26677655T>A
GRCh37.p13 chr 8NC_000008.10:g.26677655T>C
ADRA1A RefSeqGeneNG_029395.1:g.50268A>T
ADRA1A RefSeqGeneNG_029395.1:g.50268A>G

Gene: ADRA1A, adrenoceptor alpha 1A(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ADRA1A transcript variant 1NM_000680.3:c.N/AIntron Variant
ADRA1A transcript variant 5NM_001322502.1:c.N/AIntron Variant
ADRA1A transcript variant 6NM_001322503.1:c.N/AIntron Variant
ADRA1A transcript variant 7NM_001322504.1:c.N/AIntron Variant
ADRA1A transcript variant 3NM_033302.3:c.N/AIntron Variant
ADRA1A transcript variant 2NM_033303.4:c.N/AIntron Variant
ADRA1A transcript variant 4NM_033304.3:c.N/AIntron Variant
ADRA1A transcript variant 8NR_136343.1:n.N/AIntron Variant
ADRA1A transcript variant X1XM_006716292.3:c.N/AIntron Variant
ADRA1A transcript variant X4XM_006716293.3:c.N/AIntron Variant
ADRA1A transcript variant X2XM_017013094.1:c.N/AIntron Variant
ADRA1A transcript variant X3XM_017013095.1:c.N/AIntron Variant
ADRA1A transcript variant X5XM_011544411.2:c.N/AGenic Downstream Transcript Variant
ADRA1A transcript variant X9XM_011544412.2:c.N/AGenic Downstream Transcript Variant
ADRA1A transcript variant X7XM_017013096.1:c.N/AGenic Downstream Transcript Variant
ADRA1A transcript variant X6XR_001745476.1:n.N/AIntron Variant
ADRA1A transcript variant X8XR_001745477.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.073C=0.927
1000GenomesAmericanSub694T=0.150C=0.850
1000GenomesEast AsianSub1008T=0.032C=0.968
1000GenomesEuropeSub1006T=0.336C=0.664
1000GenomesGlobalStudy-wide5008T=0.143C=0.857
1000GenomesSouth AsianSub978T=0.150C=0.850
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.326C=0.674
The Genome Aggregation DatabaseAfricanSub8716T=0.103C=0.897
The Genome Aggregation DatabaseAmericanSub838T=0.170C=0.830
The Genome Aggregation DatabaseEast AsianSub1620T=0.021C=0.979
The Genome Aggregation DatabaseEuropeSub18454T=0.344C=0.655
The Genome Aggregation DatabaseGlobalStudy-wide29930T=0.250C=0.749
The Genome Aggregation DatabaseOtherSub302T=0.200C=0.800
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.203C=0.796
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.340C=0.660
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs47329000.000771cocaine dependence23958962

eQTL of rs4732900 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4732900 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr85303739853037448E06936411
chr85303751853037679E06936531
chr85296992752969992E070-30995
chr85298721552987333E070-13654
chr85298739852987452E070-13535
chr85301960953019663E07018622
chr85302477353025358E07023786
chr85301960953019663E07218622
chr85301960953019663E07418622
chr85302029853020380E07419311
chr85302059753020669E07419610
chr85298705152987126E081-13861
chr85298721552987333E081-13654
chr85298739852987452E081-13535





Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr85301344753013991E06812460
chr85301344753013991E06912460
chr85301344753013991E07012460
chr85301344753013991E07112460
chr85301344753013991E07212460
chr85301344753013991E07412460
chr85301344753013991E08212460