rs4735301

Homo sapiens
A>G
LINC00534 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0088 (2643/29954,GnomAD)
G=0070 (2060/29118,TOPMED)
G=0195 (979/5008,1000G)
G=0056 (214/3854,ALSPAC)
G=0050 (187/3708,TWINSUK)
chr8:90276439 (GRCh38.p7) (8q21.3)
AD
GWASdb2
1   publication(s)
See rs on genome
15 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.90276439A>G
GRCh37.p13 chr 8NC_000008.10:g.91288667A>G

Gene: LINC00534, long intergenic non-protein coding RNA 534(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LINC00534 transcriptNR_051989.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.967G=0.033
1000GenomesAmericanSub694A=0.670G=0.330
1000GenomesEast AsianSub1008A=0.580G=0.420
1000GenomesEuropeSub1006A=0.946G=0.054
1000GenomesGlobalStudy-wide5008A=0.805G=0.195
1000GenomesSouth AsianSub978A=0.760G=0.240
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.944G=0.056
The Genome Aggregation DatabaseAfricanSub8730A=0.954G=0.046
The Genome Aggregation DatabaseAmericanSub838A=0.590G=0.410
The Genome Aggregation DatabaseEast AsianSub1604A=0.526G=0.474
The Genome Aggregation DatabaseEuropeSub18480A=0.939G=0.060
The Genome Aggregation DatabaseGlobalStudy-wide29954A=0.911G=0.088
The Genome Aggregation DatabaseOtherSub302A=0.930G=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.929G=0.070
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.950G=0.050
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs47353010.000228alcohol dependence24277619

eQTL of rs4735301 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4735301 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr89132181291321971E06833145
chr89132216691322340E06833499
chr89132181291321971E08133145
chr89132216691322340E08133499
chr89132251291322832E08133845
chr89133240491332458E08143737
chr89133246791332640E08143800
chr89133267691332837E08144009
chr89133312991333198E08144462
chr89133325291333412E08144585
chr89126287391262960E082-25707
chr89126313791263187E082-25480
chr89126328191263762E082-24905
chr89126416491264227E082-24440
chr89126436591264415E082-24252