rs4741746

Homo sapiens
T>C
VLDLR-AS1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0157 (4725/29928,GnomAD)
C=0152 (4449/29118,TOPMED)
C=0222 (1111/5008,1000G)
C=0122 (471/3854,ALSPAC)
C=0121 (449/3708,TWINSUK)
chr9:2618969 (GRCh38.p7) (9p24.2)
ND
GWASdb2
1   publication(s)
See rs on genome
134 Enhancers around
21 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.2618969T>C
GRCh37.p13 chr 9NC_000009.11:g.2618969T>C
VLDLR RefSeqGeneNG_012741.1:g.2177T>C

Gene: VLDLR-AS1, VLDLR antisense RNA 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
VLDLR-AS1 transcriptNR_015375.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.831C=0.169
1000GenomesAmericanSub694T=0.820C=0.180
1000GenomesEast AsianSub1008T=0.594C=0.406
1000GenomesEuropeSub1006T=0.845C=0.155
1000GenomesGlobalStudy-wide5008T=0.778C=0.222
1000GenomesSouth AsianSub978T=0.800C=0.200
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.878C=0.122
The Genome Aggregation DatabaseAfricanSub8704T=0.830C=0.170
The Genome Aggregation DatabaseAmericanSub838T=0.810C=0.190
The Genome Aggregation DatabaseEast AsianSub1614T=0.648C=0.352
The Genome Aggregation DatabaseEuropeSub18470T=0.866C=0.133
The Genome Aggregation DatabaseGlobalStudy-wide29928T=0.842C=0.157
The Genome Aggregation DatabaseOtherSub302T=0.830C=0.170
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.847C=0.152
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.879C=0.121
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs47417462.98E-06nicotine smoking19268276

eQTL of rs4741746 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4741746 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr926202622620462E0671293
chr926246672624740E0675698
chr926247802624867E0675811
chr926249162625036E0675947
chr926325492632706E06713580
chr926327402633259E06713771
chr926336872633783E06714718
chr926341442634584E06715175
chr926349982635101E06716029
chr926353122635356E06716343
chr926354662635541E06716497
chr926642872664561E06745318
chr926137902614277E068-4692
chr926246672624740E0685698
chr926247802624867E0685811
chr926300672630565E06811098
chr926319192632009E06812950
chr926321022632206E06813133
chr926322732632513E06813304
chr926325492632706E06813580
chr926327402633259E06813771
chr926336872633783E06814718
chr926349982635101E06816029
chr926353122635356E06816343
chr926354662635541E06816497
chr926356682635732E06816699
chr926366002636745E06817631
chr926368482637035E06817879
chr926373412637391E06818372
chr926642872664561E06845318
chr926201512620224E0691182
chr926202622620462E0691293
chr926246672624740E0695698
chr926247802624867E0695811
chr926264822626532E0697513
chr926266602626710E0697691
chr926267142626784E0697745
chr926269062626983E0697937
chr926270282627078E0698059
chr926280712628160E0699102
chr926282142628611E0699245
chr926288432628923E0699874
chr926290052629200E06910036
chr926327402633259E06913771
chr926336872633783E06914718
chr926349982635101E06916029
chr926353122635356E06916343
chr926354662635541E06916497
chr926356682635732E06916699
chr926642872664561E06945318
chr926201512620224E0701182
chr926202622620462E0701293
chr925705532571549E071-47420
chr926201512620224E0711182
chr926202622620462E0711293
chr926246672624740E0715698
chr926247802624867E0715811
chr926264822626532E0717513
chr926266602626710E0717691
chr926267142626784E0717745
chr926269062626983E0717937
chr926270282627078E0718059
chr926300672630565E07111098
chr926319192632009E07112950
chr926321022632206E07113133
chr926322732632513E07113304
chr926327402633259E07113771
chr926336872633783E07114718
chr926349982635101E07116029
chr926353122635356E07116343
chr926354662635541E07116497
chr926356682635732E07116699
chr926366002636745E07117631
chr926622612662311E07143292
chr926627942662912E07143825
chr926629552663015E07143986
chr926630292663078E07144060
chr926642872664561E07145318
chr926156872615950E072-3019
chr926321022632206E07213133
chr926322732632513E07213304
chr926325492632706E07213580
chr926327402633259E07213771
chr926336872633783E07214718
chr926353122635356E07216343
chr926366002636745E07217631
chr926368482637035E07217879
chr926373412637391E07218372
chr926395512639657E07220582
chr926397202640199E07220751
chr926622612662311E07243292
chr926627942662912E07243825
chr926629552663015E07243986
chr926642872664561E07245318
chr926246672624740E0735698
chr926247802624867E0735811
chr926249162625036E0735947
chr925705532571549E074-47420
chr925766142576791E074-42178
chr925768052576917E074-42052
chr925770042577196E074-41773
chr926152012615277E074-3692
chr926156872615950E074-3019
chr926201512620224E0741182
chr926202622620462E0741293
chr926264822626532E0747513
chr926266602626710E0747691
chr926267142626784E0747745
chr926321022632206E07413133
chr926322732632513E07413304
chr926325492632706E07413580
chr926327402633259E07413771
chr926336872633783E07414718
chr926349982635101E07416029
chr926356682635732E07416699
chr926366002636745E07417631
chr926395512639657E07420582
chr926397202640199E07420751
chr926622612662311E07443292
chr926114102611777E081-7192
chr926120302612269E081-6700
chr926125562612606E081-6363
chr926201512620224E0811182
chr926202622620462E0811293
chr926246672624740E0815698
chr926247802624867E0815811
chr926249162625036E0815947
chr926255932625819E0816624
chr926264822626532E0817513
chr926327402633259E08113771
chr926336872633783E08114718
chr926341442634584E08115175
chr926255932625819E0826624
chr926341442634584E08215175










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr926207892620867E0671820
chr926209062624528E0671937
chr926205442620662E0681575
chr926207892620867E0681820
chr926209062624528E0681937
chr926209062624528E0691937
chr926205442620662E0701575
chr926207892620867E0701820
chr926209062624528E0701937
chr926207892620867E0711820
chr926209062624528E0711937
chr926207892620867E0721820
chr926209062624528E0721937
chr926209062624528E0731937
chr926209062624528E0741937
chr926205442620662E0811575
chr926207892620867E0811820
chr926209062624528E0811937
chr926205442620662E0821575
chr926207892620867E0821820
chr926209062624528E0821937