rs4757574

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0291 (8723/29958,GnomAD)
A==0336 (9787/29118,TOPMED)
A==0281 (1409/5008,1000G)
A==0256 (988/3854,ALSPAC)
A==0254 (943/3708,TWINSUK)
chr11:17704827 (GRCh38.p7) (11p15.1)
AD
GWASdb2
3   publication(s)
See rs on genome
30 Enhancers around
29 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.17704827A>G
GRCh37.p13 chr 11NC_000011.9:g.17726374A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.505G=0.495
1000GenomesAmericanSub694A=0.260G=0.740
1000GenomesEast AsianSub1008A=0.044G=0.956
1000GenomesEuropeSub1006A=0.253G=0.747
1000GenomesGlobalStudy-wide5008A=0.281G=0.719
1000GenomesSouth AsianSub978A=0.270G=0.730
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.256G=0.744
The Genome Aggregation DatabaseAfricanSub8712A=0.468G=0.532
The Genome Aggregation DatabaseAmericanSub834A=0.220G=0.780
The Genome Aggregation DatabaseEast AsianSub1618A=0.023G=0.977
The Genome Aggregation DatabaseEuropeSub18492A=0.235G=0.764
The Genome Aggregation DatabaseGlobalStudy-wide29958A=0.291G=0.708
The Genome Aggregation DatabaseOtherSub302A=0.220G=0.780
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.336G=0.663
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.254G=0.746
PMID Title Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.Heath ACBiol Psychiatry
20678250Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees.Coon HMol Autism
19264455Linkage analysis of schizophrenia in African-American families.Wiener HWSchizophr Res

P-Value

SNP ID p-value Traits Study
rs47575740.0001alcoholism (heaviness of drinking)21529783

eQTL of rs4757574 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4757574 in Fetal Brain

Probe ID Position Gene beta p-value
cg01144436chr11:177439460.03708501065488378.3619e-9

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr111772271617722926E067-3448
chr111777142717771477E06745053
chr111777298217773109E06746608
chr111777326917773399E06746895
chr111777610317776163E06749729
chr111777142717771477E06945053
chr111777326917773399E07146895
chr111777114317771193E07244769
chr111777142717771477E07245053
chr111777189917772081E07245525
chr111776987117769948E07343497
chr111777142717771477E07345053
chr111772225617722436E074-3938
chr111772271617722926E074-3448
chr111775311117753214E08126737
chr111775329217753407E08126918
chr111775441117754451E08128037
chr111775447317754553E08128099
chr111775903217759122E08132658
chr111775918517759245E08132811
chr111775931817759398E08132944
chr111775944417759494E08133070
chr111775999617760091E08133622
chr111776010417760154E08133730
chr111776504517765361E08138671
chr111776538117765520E08139007
chr111775552317755583E08229149
chr111776363617763761E08237262
chr111776394017764001E08237566
chr111776444017764702E08238066








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr111774280617742996E06716432
chr111775582917758005E06729455
chr111776125117761407E06734877
chr111776141117761625E06735037
chr111775582917758005E06829455
chr111776125117761407E06834877
chr111775582917758005E06929455
chr111776125117761407E06934877
chr111776141117761625E06935037
chr111775563217755815E07029258
chr111775582917758005E07029455
chr111776125117761407E07034877
chr111776141117761625E07035037
chr111774280617742996E07116432
chr111775563217755815E07129258
chr111775582917758005E07129455
chr111774280617742996E07216432
chr111775563217755815E07229258
chr111775582917758005E07229455
chr111776125117761407E07234877
chr111776141117761625E07235037
chr111775582917758005E07329455
chr111776125117761407E07334877
chr111776141117761625E07335037
chr111776125117761407E08134877
chr111775563217755815E08229258
chr111775582917758005E08229455
chr111776125117761407E08234877
chr111776141117761625E08235037