rs4758259

Homo sapiens
C>T
OR10A3 : 2KB Upstream Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0325 (9750/29918,GnomAD)
T=0320 (9340/29118,TOPMED)
T=0320 (1605/5008,1000G)
T=0379 (1462/3854,ALSPAC)
T=0375 (1390/3708,TWINSUK)
chr11:7939583 (GRCh38.p7) (11p15.4)
AD
GWASdb2
1   publication(s)
See rs on genome
24 Enhancers around
31 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.7939583C>T
GRCh37.p13 chr 11NC_000011.9:g.7961130C>T
GRCh38.p7 chr 11 novel patch HSCHR11_1_CTG1_2NW_011332695.1:g.170577C>T
GRCh38.p7 chr 11 alt locus HSCHR11_1_CTG5NT_187583.1:g.171084C>T

Gene: OR10A3, olfactory receptor family 10 subfamily A member 3(minus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
OR10A3 transcriptNM_001003745.1:c.N/AUpstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.766T=0.234
1000GenomesAmericanSub694C=0.540T=0.460
1000GenomesEast AsianSub1008C=0.736T=0.264
1000GenomesEuropeSub1006C=0.646T=0.354
1000GenomesGlobalStudy-wide5008C=0.680T=0.320
1000GenomesSouth AsianSub978C=0.630T=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.621T=0.379
The Genome Aggregation DatabaseAfricanSub8708C=0.742T=0.258
The Genome Aggregation DatabaseAmericanSub838C=0.560T=0.440
The Genome Aggregation DatabaseEast AsianSub1614C=0.714T=0.286
The Genome Aggregation DatabaseEuropeSub18456C=0.642T=0.357
The Genome Aggregation DatabaseGlobalStudy-wide29918C=0.674T=0.325
The Genome Aggregation DatabaseOtherSub302C=0.770T=0.230
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.679T=0.320
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.625T=0.375
PMID Title Author Journal
23953852Genome-wide association studies of maximum number of drinks.Pan YJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs47582597.86E-05alcohol consumption23953852

eQTL of rs4758259 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4758259 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1180076118007848E06746481
chr1180105818010710E06749451
chr1180076118007848E06846481
chr1180105818010710E06849451
chr1180076118007848E06946481
chr1180105818010710E06949451
chr1179858687986265E07024738
chr1180076118007848E07046481
chr1180105818010710E07049451
chr1180105818010710E07149451
chr1180072428007477E07246112
chr1180075268007574E07246396
chr1180076118007848E07246481
chr1180105818010710E07249451
chr1180076118007848E07346481
chr1180105818010710E07349451
chr1180076118007848E07446481
chr1180105818010710E07449451
chr1179858687986265E08224738
chr1180069938007037E08245863
chr1180072428007477E08246112
chr1180075268007574E08246396
chr1180076118007848E08246481
chr1180105818010710E08249451









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1180078508009092E06746720
chr1180092438009487E06748113
chr1180094988009671E06748368
chr1180078508009092E06846720
chr1180092438009487E06848113
chr1180094988009671E06848368
chr1180078508009092E06946720
chr1180092438009487E06948113
chr1180094988009671E06948368
chr1180078508009092E07046720
chr1180092438009487E07048113
chr1180094988009671E07048368
chr1180078508009092E07146720
chr1180092438009487E07148113
chr1180094988009671E07148368
chr1180078508009092E07246720
chr1180092438009487E07248113
chr1180094988009671E07248368
chr1180078508009092E07346720
chr1180092438009487E07348113
chr1180094988009671E07348368
chr1179492487949467E074-11663
chr1179494767949625E074-11505
chr1180078508009092E07446720
chr1180092438009487E07448113
chr1180094988009671E07448368
chr1180092438009487E08148113
chr1180094988009671E08148368
chr1180078508009092E08246720
chr1180092438009487E08248113
chr1180094988009671E08248368