rs4758621

Homo sapiens
A>G
NAP1L4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0257 (7702/29952,GnomAD)
G=0242 (7074/29118,TOPMED)
G=0367 (1838/5008,1000G)
G=0311 (1197/3854,ALSPAC)
G=0297 (1102/3708,TWINSUK)
chr11:2988410 (GRCh38.p7) (11p15.4)
AD
GWASdb2
2   publication(s)
See rs on genome
295 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.2988410A>G
GRCh37.p13 chr 11NC_000011.9:g.3009640A>G
GRCh38.p7 chr 11 alt locus HSCHR11_1_CTG7NT_187585.1:g.219480G>A

Gene: NAP1L4, nucleosome assembly protein 1 like 4(minus strand)

Molecule type Change Amino acid[Codon] SO Term
NAP1L4 transcriptNM_005969.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.973G=0.027
1000GenomesAmericanSub694A=0.480G=0.520
1000GenomesEast AsianSub1008A=0.296G=0.704
1000GenomesEuropeSub1006A=0.687G=0.313
1000GenomesGlobalStudy-wide5008A=0.633G=0.367
1000GenomesSouth AsianSub978A=0.580G=0.420
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.689G=0.311
The Genome Aggregation DatabaseAfricanSub8726A=0.925G=0.075
The Genome Aggregation DatabaseAmericanSub836A=0.460G=0.540
The Genome Aggregation DatabaseEast AsianSub1616A=0.304G=0.696
The Genome Aggregation DatabaseEuropeSub18472A=0.709G=0.290
The Genome Aggregation DatabaseGlobalStudy-wide29952A=0.742G=0.257
The Genome Aggregation DatabaseOtherSub302A=0.650G=0.350
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.757G=0.242
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.703G=0.297
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
21911749CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.Hu CDiabetes

P-Value

SNP ID p-value Traits Study
rs47586210.00037alcohol dependence20201924

eQTL of rs4758621 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4758621 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1129662952967764E067-41876
chr1130034183003948E067-5692
chr1130044323004472E067-5168
chr1130044753004606E067-5034
chr1130083713008482E067-1158
chr1130085403008614E067-1026
chr1130090683009383E067-257
chr1130197123019867E06710072
chr1130199653020015E06710325
chr1130206083020715E06710968
chr1130207813020831E06711141
chr1130209853021035E06711345
chr1130213433023046E06711703
chr1130231133023234E06713473
chr1130232433023293E06713603
chr1130233113023375E06713671
chr1130235313023614E06713891
chr1130238543023904E06714214
chr1130242343024284E06714594
chr1130245403024669E06714900
chr1130246863024736E06715046
chr1130250523025109E06715412
chr1130251573025416E06715517
chr1130256733025723E06716033
chr1130420223042072E06732382
chr1130422623042740E06732622
chr1130511793051219E06741539
chr1130513803051434E06741740
chr1130515143051804E06741874
chr1130564463056535E06746806
chr1130566183056925E06746978
chr1130576093058080E06747969
chr1129648972964968E068-44672
chr1129662952967764E068-41876
chr1129680632968136E068-41504
chr1129690922969179E068-40461
chr1130034183003948E068-5692
chr1130044323004472E068-5168
chr1130044753004606E068-5034
chr1130046313004681E068-4959
chr1130047883004842E068-4798
chr1130206083020715E06810968
chr1130207813020831E06811141
chr1130209853021035E06811345
chr1130231133023234E06813473
chr1130232433023293E06813603
chr1130233113023375E06813671
chr1130235313023614E06813891
chr1130238543023904E06814214
chr1130242343024284E06814594
chr1130245403024669E06814900
chr1130246863024736E06815046
chr1130250523025109E06815412
chr1130251573025416E06815517
chr1130256733025723E06816033
chr1130259883026062E06816348
chr1130271013027156E06817461
chr1130420223042072E06832382
chr1130422623042740E06832622
chr1130429893043063E06833349
chr1130432503043327E06833610
chr1130434703044622E06833830
chr1130583013059394E06848661
chr1129662952967764E069-41876
chr1129968922997117E069-12523
chr1129971372997477E069-12163
chr1129975392997788E069-11852
chr1129978042998183E069-11457
chr1130034183003948E069-5692
chr1130044323004472E069-5168
chr1130044753004606E069-5034
chr1130046313004681E069-4959
chr1130047883004842E069-4798
chr1130083713008482E069-1158
chr1130206083020715E06910968
chr1130207813020831E06911141
chr1130209853021035E06911345
chr1130231133023234E06913473
chr1130232433023293E06913603
chr1130233113023375E06913671
chr1130235313023614E06913891
chr1130238543023904E06914214
chr1130242343024284E06914594
chr1130245403024669E06914900
chr1130246863024736E06915046
chr1130250523025109E06915412
chr1130251573025416E06915517
chr1130310653031130E06921425
chr1130312013031261E06921561
chr1130418503041909E06932210
chr1130420223042072E06932382
chr1130422623042740E06932622
chr1130434703044622E06933830
chr1130446673044748E06935027
chr1130501743050295E06940534
chr1130503373050432E06940697
chr1130505563050763E06940916
chr1130511793051219E06941539
chr1130513803051434E06941740
chr1130515143051804E06941874
chr1130583013059394E06948661
chr1129662952967764E070-41876
chr1130033003003360E070-6280
chr1130034183003948E070-5692
chr1129612242962992E071-46648
chr1129659982966209E071-43431
chr1129662952967764E071-41876
chr1129680632968136E071-41504
chr1130034183003948E071-5692
chr1130044323004472E071-5168
chr1130044753004606E071-5034
chr1130046313004681E071-4959
chr1130047883004842E071-4798
chr1130049403004995E071-4645
chr1130083713008482E071-1158
chr1130085403008614E071-1026
chr1130090683009383E071-257
chr1130206083020715E07110968
chr1130207813020831E07111141
chr1130209853021035E07111345
chr1130231133023234E07113473
chr1130232433023293E07113603
chr1130233113023375E07113671
chr1130235313023614E07113891
chr1130238543023904E07114214
chr1130242343024284E07114594
chr1130245403024669E07114900
chr1130246863024736E07115046
chr1130250523025109E07115412
chr1130251573025416E07115517
chr1130256733025723E07116033
chr1130309213030975E07121281
chr1130310653031130E07121425
chr1130312013031261E07121561
chr1130346583034866E07125018
chr1130350633035174E07125423
chr1130365123036578E07126872
chr1130366553036836E07127015
chr1130418503041909E07132210
chr1130420223042072E07132382
chr1130422623042740E07132622
chr1130503373050432E07140697
chr1130505563050763E07140916
chr1130511793051219E07141539
chr1130513803051434E07141740
chr1130515143051804E07141874
chr1130518653052209E07142225
chr1130576093058080E07147969
chr1130583013059394E07148661
chr1129662952967764E072-41876
chr1129680632968136E072-41504
chr1129860272986242E072-23398
chr1129863492986409E072-23231
chr1129968922997117E072-12523
chr1129971372997477E072-12163
chr1129975392997788E072-11852
chr1129978042998183E072-11457
chr1130024623002554E072-7086
chr1130026943002744E072-6896
chr1130030563003286E072-6354
chr1130033003003360E072-6280
chr1130034183003948E072-5692
chr1130044323004472E072-5168
chr1130044753004606E072-5034
chr1130046313004681E072-4959
chr1130047883004842E072-4798
chr1130049403004995E072-4645
chr1130090683009383E072-257
chr1130206083020715E07210968
chr1130207813020831E07211141
chr1130209853021035E07211345
chr1130213433023046E07211703
chr1130231133023234E07213473
chr1130232433023293E07213603
chr1130233113023375E07213671
chr1130235313023614E07213891
chr1130238543023904E07214214
chr1130242343024284E07214594
chr1130245403024669E07214900
chr1130246863024736E07215046
chr1130250523025109E07215412
chr1130251573025416E07215517
chr1130256733025723E07216033
chr1130259883026062E07216348
chr1130309213030975E07221281
chr1130310653031130E07221425
chr1130312013031261E07221561
chr1130317513031801E07222111
chr1130319633032013E07222323
chr1130321823032490E07222542
chr1130366553036836E07227015
chr1130368513036917E07227211
chr1130418503041909E07232210
chr1130420223042072E07232382
chr1130422623042740E07232622
chr1130511793051219E07241539
chr1130513803051434E07241740
chr1130515143051804E07241874
chr1130576093058080E07247969
chr1130583013059394E07248661
chr1129649882965377E073-44263
chr1129654892965649E073-43991
chr1129657452965809E073-43831
chr1129658372965970E073-43670
chr1129659982966209E073-43431
chr1129662952967764E073-41876
chr1129975392997788E073-11852
chr1129978042998183E073-11457
chr1130030563003286E073-6354
chr1130033003003360E073-6280
chr1130034183003948E073-5692
chr1130081743008263E073-1377
chr1130083713008482E073-1158
chr1130085403008614E073-1026
chr1130090683009383E073-257
chr1130206083020715E07310968
chr1130207813020831E07311141
chr1130209853021035E07311345
chr1130213433023046E07311703
chr1130231133023234E07313473
chr1130232433023293E07313603
chr1130233113023375E07313671
chr1130235313023614E07313891
chr1130238543023904E07314214
chr1130242343024284E07314594
chr1130251573025416E07315517
chr1130256733025723E07316033
chr1130309213030975E07321281
chr1130310653031130E07321425
chr1130312013031261E07321561
chr1130420223042072E07332382
chr1130422623042740E07332622
chr1130511793051219E07341539
chr1130513803051434E07341740
chr1130515143051804E07341874
chr1130576093058080E07347969
chr1130583013059394E07348661
chr1129662952967764E074-41876
chr1129999033000044E074-9596
chr1130030563003286E074-6354
chr1130033003003360E074-6280
chr1130034183003948E074-5692
chr1130044323004472E074-5168
chr1130044753004606E074-5034
chr1130046313004681E074-4959
chr1130047883004842E074-4798
chr1130049403004995E074-4645
chr1130081743008263E074-1377
chr1130083713008482E074-1158
chr1130085403008614E074-1026
chr1130188263018892E0749186
chr1130190553019389E0749415
chr1130206083020715E07410968
chr1130207813020831E07411141
chr1130209853021035E07411345
chr1130213433023046E07411703
chr1130231133023234E07413473
chr1130235313023614E07413891
chr1130238543023904E07414214
chr1130242343024284E07414594
chr1130245403024669E07414900
chr1130246863024736E07415046
chr1130250523025109E07415412
chr1130251573025416E07415517
chr1130256733025723E07416033
chr1130266363026866E07416996
chr1130269373026988E07417297
chr1130271013027156E07417461
chr1130310653031130E07421425
chr1130312013031261E07421561
chr1130317513031801E07422111
chr1130350633035174E07425423
chr1130418503041909E07432210
chr1130420223042072E07432382
chr1130422623042740E07432622
chr1130511793051219E07441539
chr1130513803051434E07441740
chr1130515143051804E07441874
chr1130518653052209E07442225
chr1130583013059394E07448661
chr1129657452965809E081-43831
chr1129658372965970E081-43670
chr1129659982966209E081-43431
chr1129662952967764E081-41876
chr1129680632968136E081-41504
chr1129682072968269E081-41371
chr1129683532968484E081-41156
chr1129685042968589E081-41051
chr1129686002968740E081-40900
chr1130207813020831E08111141
chr1130209853021035E08111345
chr1130213433023046E08111703
chr1129680632968136E082-41504
chr1130090683009383E082-257
chr1130213433023046E08211703










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1130117713011832E0672131
chr1130118583014423E0672218
chr1130117713011832E0682131
chr1130118583014423E0682218
chr1130117713011832E0692131
chr1130118583014423E0692218
chr1130117713011832E0702131
chr1130118583014423E0702218
chr1130117713011832E0712131
chr1130118583014423E0712218
chr1130117713011832E0722131
chr1130118583014423E0722218
chr1130117713011832E0732131
chr1130118583014423E0732218
chr1130117713011832E0742131
chr1130118583014423E0742218
chr1130117713011832E0812131
chr1130117713011832E0822131
chr1130118583014423E0822218