rs4774925

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0436 (13053/29928,GnomAD)
T==0483 (2418/5008,1000G)
T==0371 (1431/3854,ALSPAC)
T==0382 (1416/3708,TWINSUK)
chr15:57312204 (GRCh38.p7) (15q21.3)
ND
GWASdb2
1   publication(s)
See rs on genome
88 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.57312204T>C
GRCh37.p13 chr 15NC_000015.9:g.57604402T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.688C=0.312
1000GenomesAmericanSub694T=0.330C=0.670
1000GenomesEast AsianSub1008T=0.531C=0.469
1000GenomesEuropeSub1006T=0.352C=0.648
1000GenomesGlobalStudy-wide5008T=0.483C=0.517
1000GenomesSouth AsianSub978T=0.400C=0.600
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.371C=0.629
The Genome Aggregation DatabaseAfricanSub8710T=0.645C=0.355
The Genome Aggregation DatabaseAmericanSub838T=0.340C=0.660
The Genome Aggregation DatabaseEast AsianSub1616T=0.551C=0.449
The Genome Aggregation DatabaseEuropeSub18464T=0.332C=0.667
The Genome Aggregation DatabaseGlobalStudy-wide29928T=0.436C=0.563
The Genome Aggregation DatabaseOtherSub300T=0.440C=0.560
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.382C=0.618
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs47749259.85E-05nicotine smoking19268276

eQTL of rs4774925 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr15:57604402LINC00926ENSG00000247982.2T>C8.3400e-2511839Cerebellum
Chr15:57604402LINC00926ENSG00000247982.2T>C1.7516e-1611839Cerebellar_Hemisphere

meQTL of rs4774925 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr155756437557564419E067-39983
chr155756500957565059E067-39343
chr155756527657565419E067-38983
chr155756549457565574E067-38828
chr155756558857566061E067-38341
chr155756700657567082E067-37320
chr155756735957567468E067-36934
chr155756765257567702E067-36700
chr155756793857567978E067-36424
chr155759046557590748E067-13654
chr155759079857590947E067-13455
chr155759109757591350E067-13052
chr155755800257558167E068-46235
chr155756500957565059E068-39343
chr155756527657565419E068-38983
chr155756549457565574E068-38828
chr155756558857566061E068-38341
chr155758933457589830E068-14572
chr155759800557598109E068-6293
chr155761261557613438E0688213
chr155761528757615622E06810885
chr155761569157617115E06811289
chr155756348557563605E069-40797
chr155756373357563789E069-40613
chr155756414557564208E069-40194
chr155756437557564419E069-39983
chr155756500957565059E069-39343
chr155756527657565419E069-38983
chr155756549457565574E069-38828
chr155756558857566061E069-38341
chr155756614457566194E069-38208
chr155758875757589330E069-15072
chr155759079857590947E069-13455
chr155759109757591350E069-13052
chr155761261557613438E0698213
chr155756527657565419E070-38983
chr155756549457565574E070-38828
chr155756558857566061E070-38341
chr155760237257602832E070-1570
chr155760290757602974E070-1428
chr155756414557564208E071-40194
chr155756437557564419E071-39983
chr155756500957565059E071-39343
chr155756527657565419E071-38983
chr155756549457565574E071-38828
chr155756558857566061E071-38341
chr155756614457566194E071-38208
chr155756700657567082E071-37320
chr155756735957567468E071-36934
chr155756765257567702E071-36700
chr155756793857567978E071-36424
chr155759046557590748E071-13654
chr155759079857590947E071-13455
chr155759109757591350E071-13052
chr155756437557564419E072-39983
chr155756500957565059E072-39343
chr155756527657565419E072-38983
chr155756549457565574E072-38828
chr155756558857566061E072-38341
chr155757365957573834E072-30568
chr155759046557590748E072-13654
chr155759079857590947E072-13455
chr155759109757591350E072-13052
chr155759138457591774E072-12628
chr155756500957565059E073-39343
chr155756527657565419E073-38983
chr155756549457565574E073-38828
chr155756558857566061E073-38341
chr155756373357563789E074-40613
chr155756437557564419E074-39983
chr155756500957565059E074-39343
chr155756527657565419E074-38983
chr155756549457565574E074-38828
chr155756558857566061E074-38341
chr155758933457589830E074-14572
chr155759046557590748E074-13654
chr155759079857590947E074-13455
chr155757845257578571E081-25831
chr155757860757578686E081-25716
chr155757876157579215E081-25187
chr155757939357579524E081-24878
chr155757956257579660E081-24742
chr155761251157612586E0818109
chr155761569157617115E08111289
chr155757956257579660E082-24742
chr155757966257580210E082-24192
chr155758875757589330E082-15072
chr155758933457589830E082-14572










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr155759815357599661E067-4741
chr155759815357599661E068-4741
chr155759815357599661E069-4741
chr155759815357599661E070-4741
chr155759815357599661E071-4741
chr155759815357599661E072-4741
chr155759815357599661E073-4741
chr155759815357599661E074-4741
chr155759815357599661E082-4741