rs4821261

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0091 (2732/29732,GnomAD)
T==0087 (2541/29114,TOPMED)
T==0062 (312/5008,1000G)
T==0134 (518/3854,ALSPAC)
T==0136 (504/3708,TWINSUK)
chr22:34545584 (GRCh38.p7) (22q12.3)
AD
GWASCatalog
1   publication(s)
See rs on genome
8 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.34545584T>C
GRCh37.p13 chr 22NC_000022.10:g.34941576T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.044C=0.956
1000GenomesAmericanSub694T=0.070C=0.930
1000GenomesEast AsianSub1008T=0.047C=0.953
1000GenomesEuropeSub1006T=0.110C=0.890
1000GenomesGlobalStudy-wide5008T=0.062C=0.938
1000GenomesSouth AsianSub978T=0.050C=0.950
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.134C=0.866
The Genome Aggregation DatabaseAfricanSub8670T=0.054C=0.946
The Genome Aggregation DatabaseAmericanSub838T=0.070C=0.930
The Genome Aggregation DatabaseEast AsianSub1614T=0.059C=0.941
The Genome Aggregation DatabaseEuropeSub18308T=0.112C=0.887
The Genome Aggregation DatabaseGlobalStudy-wide29732T=0.091C=0.908
The Genome Aggregation DatabaseOtherSub302T=0.180C=0.820
Trans-Omics for Precision MedicineGlobalStudy-wide29114T=0.087C=0.912
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.136C=0.864
PMID Title Author Journal
23942779A genome-wide association study of behavioral disinhibition.McGue MBehav Genet

P-Value

SNP ID p-value Traits Study
rs48212619E-06alcohol dependence23942779

eQTL of rs4821261 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4821261 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr223489634434896414E081-45162
chr223489642834896502E081-45074
chr223489686134896905E081-44671
chr223489717134897223E081-44353
chr223489745234897682E081-43894
chr223489782534898050E081-43526
chr223489831634898366E081-43210
chr223489871234899210E081-42366