rs4837408

Homo sapiens
C>T
PTGES : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0098 (2948/29918,GnomAD)
T=0111 (3258/29118,TOPMED)
T=0130 (650/5008,1000G)
T=0072 (278/3854,ALSPAC)
T=0079 (293/3708,TWINSUK)
chr9:129751861 (GRCh38.p7) (9q34.11)
ND
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.129751861C>T
GRCh37.p13 chr 9NC_000009.11:g.132514140C>T

Gene: PTGES, prostaglandin E synthase(minus strand)

Molecule type Change Amino acid[Codon] SO Term
PTGES transcriptNM_004878.4:c.N/AIntron Variant
PTGES transcript variant X1XM_011519210.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.862T=0.138
1000GenomesAmericanSub694C=0.900T=0.100
1000GenomesEast AsianSub1008C=0.816T=0.184
1000GenomesEuropeSub1006C=0.935T=0.065
1000GenomesGlobalStudy-wide5008C=0.870T=0.130
1000GenomesSouth AsianSub978C=0.850T=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.928T=0.072
The Genome Aggregation DatabaseAfricanSub8714C=0.865T=0.135
The Genome Aggregation DatabaseAmericanSub838C=0.880T=0.120
The Genome Aggregation DatabaseEast AsianSub1616C=0.830T=0.170
The Genome Aggregation DatabaseEuropeSub18450C=0.926T=0.074
The Genome Aggregation DatabaseGlobalStudy-wide29918C=0.901T=0.098
The Genome Aggregation DatabaseOtherSub300C=0.910T=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.888T=0.111
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.921T=0.079
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs48374080.000636nicotine dependence17158188

eQTL of rs4837408 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4837408 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr9132474008132475874E067-38266
chr9132488086132489417E067-24723
chr9132464704132465856E068-48284
chr9132465974132466616E068-47524
chr9132477400132477527E068-36613
chr9132499257132499325E068-14815
chr9132499397132499603E068-14537
chr9132499653132499703E068-14437
chr9132538822132540233E06824682
chr9132476717132477382E069-36758
chr9132477400132477527E069-36613
chr9132488086132489417E069-24723
chr9132499653132499703E069-14437
chr9132538822132540233E06924682
chr9132545974132546470E06931834
chr9132474008132475874E070-38266
chr9132477400132477527E070-36613
chr9132487692132488006E070-26134
chr9132488086132489417E070-24723
chr9132489487132489579E070-24561
chr9132489680132489756E070-24384
chr9132464704132465856E071-48284
chr9132474008132475874E071-38266
chr9132488086132489417E071-24723
chr9132474008132475874E072-38266
chr9132488086132489417E072-24723
chr9132499257132499325E072-14815
chr9132499397132499603E072-14537
chr9132499653132499703E072-14437
chr9132538822132540233E07224682
chr9132476717132477382E073-36758
chr9132488086132489417E073-24723
chr9132499397132499603E073-14537
chr9132499653132499703E073-14437
chr9132464704132465856E074-48284
chr9132474008132475874E074-38266
chr9132476717132477382E074-36758
chr9132477400132477527E074-36613
chr9132477984132478303E074-35837
chr9132478506132478638E074-35502
chr9132488086132489417E074-24723
chr9132538822132540233E07424682
chr9132474008132475874E081-38266