rs4859305

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0458 (13698/29910,GnomAD)
T==0460 (13417/29118,TOPMED)
T==0450 (2252/5008,1000G)
T==0491 (1891/3854,ALSPAC)
C=0499 (1852/3708,TWINSUK)
chr4:35520415 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35520415T>C
GRCh37.p13 chr 4NC_000004.11:g.35522037T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.401C=0.599
1000GenomesAmericanSub694T=0.530C=0.470
1000GenomesEast AsianSub1008T=0.300C=0.700
1000GenomesEuropeSub1006T=0.465C=0.535
1000GenomesGlobalStudy-wide5008T=0.450C=0.550
1000GenomesSouth AsianSub978T=0.600C=0.400
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.491C=0.509
The Genome Aggregation DatabaseAfricanSub8700T=0.413C=0.587
The Genome Aggregation DatabaseAmericanSub838T=0.570C=0.430
The Genome Aggregation DatabaseEast AsianSub1612T=0.261C=0.739
The Genome Aggregation DatabaseEuropeSub18458T=0.491C=0.508
The Genome Aggregation DatabaseGlobalStudy-wide29910T=0.458C=0.542
The Genome Aggregation DatabaseOtherSub302T=0.420C=0.580
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.460C=0.539
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.501C=0.499
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs48593050.000215nicotine dependence17158188

eQTL of rs4859305 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4859305 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E0744700
chr43553670135536912E08214664
chr43553699835537160E08214961


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E0684835
chr43552703435527236E0684997
chr43552753335527608E0685496
chr43552687235526986E0694835
chr43552703435527236E0694997
chr43552687235526986E0714835
chr43552703435527236E0714997
chr43552753335527608E0715496
chr43552687235526986E0724835
chr43552703435527236E0724997
chr43552687235526986E0734835
chr43552703435527236E0734997
chr43552687235526986E0744835
chr43552703435527236E0744997