rs4859306

Homo sapiens
A>C / A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0457 (13634/29818,GnomAD)
A==0460 (13415/29118,TOPMED)
A==0449 (2251/5008,1000G)
A==0491 (1891/3854,ALSPAC)
G=0499 (1852/3708,TWINSUK)
chr4:35520575 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
18 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35520575A>C
GRCh38.p7 chr 4NC_000004.12:g.35520575A>G
GRCh37.p13 chr 4NC_000004.11:g.35522197A>C
GRCh37.p13 chr 4NC_000004.11:g.35522197A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.400G=0.600
1000GenomesAmericanSub694A=0.530G=0.470
1000GenomesEast AsianSub1008A=0.300G=0.700
1000GenomesEuropeSub1006A=0.465G=0.535
1000GenomesGlobalStudy-wide5008A=0.449G=0.551
1000GenomesSouth AsianSub978A=0.600G=0.400
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.491G=0.509
The Genome Aggregation DatabaseAfricanSub8700A=0.412G=0.587
The Genome Aggregation DatabaseAmericanSub838A=0.570G=0.43,
The Genome Aggregation DatabaseEast AsianSub1602A=0.260G=0.740
The Genome Aggregation DatabaseEuropeSub18376A=0.491G=0.508
The Genome Aggregation DatabaseGlobalStudy-wide29818A=0.457G=0.542
The Genome Aggregation DatabaseOtherSub302A=0.420G=0.58,
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.460G=0.539
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.501G=0.499
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs48593060.000231nicotine dependence17158188

eQTL of rs4859306 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4859306 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E07411327
chr43553670135536912E08221291
chr43553699835537160E08221588


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43546683035466880E067-48530
chr43552687235526986E06811462
chr43552703435527236E06811624
chr43552753335527608E06812123
chr43546683035466880E069-48530
chr43552687235526986E06911462
chr43552703435527236E06911624
chr43546683035466880E071-48530
chr43552687235526986E07111462
chr43552703435527236E07111624
chr43552753335527608E07112123
chr43546683035466880E072-48530
chr43552687235526986E07211462
chr43552703435527236E07211624
chr43552687235526986E07311462
chr43552703435527236E07311624
chr43552687235526986E07411462
chr43552703435527236E07411624