SNP Detail Info-rs4859365

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0457 (13649/29818,GnomAD)
G==0460 (13409/29118,TOPMED)
G==0450 (2252/5008,1000G)
G==0491 (1893/3854,ALSPAC)
A=0498 (1845/3708,TWINSUK)

Position: chr4:35520910 (GRCh38.p7) (4p15.1)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 3 Enhancers around

Promoter: 14 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 4	NC_000004.12:g.35520910G>A
GRCh37.p13 chr 4	NC_000004.11:g.35522532G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.401	A=0.599
1000Genomes	American	Sub	694	G=0.530	A=0.470
1000Genomes	East Asian	Sub	1008	G=0.300	A=0.700
1000Genomes	Europe	Sub	1006	G=0.465	A=0.535
1000Genomes	Global	Study-wide	5008	G=0.450	A=0.550
1000Genomes	South Asian	Sub	978	G=0.600	A=0.400
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.491	A=0.509
The Genome Aggregation Database	African	Sub	8678	G=0.412	A=0.588
The Genome Aggregation Database	American	Sub	828	G=0.570	A=0.430
The Genome Aggregation Database	East Asian	Sub	1612	G=0.261	A=0.739
The Genome Aggregation Database	Europe	Sub	18400	G=0.492	A=0.507
The Genome Aggregation Database	Global	Study-wide	29818	G=0.457	A=0.542
The Genome Aggregation Database	Other	Sub	300	G=0.420	A=0.580
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.460	A=0.539
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.502	A=0.498

PMID	Title	Author	Journal
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

SNP ID	p-value	Traits	Study
rs4859365	7.72E-05	nicotine dependence	17158188

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr4	35526737	35526787	E074	4205
chr4	35536701	35536912	E082	14169
chr4	35536998	35537160	E082	14466

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr4	35526872	35526986	E068	4340
chr4	35527034	35527236	E068	4502
chr4	35527533	35527608	E068	5001
chr4	35526872	35526986	E069	4340
chr4	35527034	35527236	E069	4502
chr4	35526872	35526986	E071	4340
chr4	35527034	35527236	E071	4502
chr4	35527533	35527608	E071	5001
chr4	35526872	35526986	E072	4340
chr4	35527034	35527236	E072	4502
chr4	35526872	35526986	E073	4340
chr4	35527034	35527236	E073	4502
chr4	35526872	35526986	E074	4340
chr4	35527034	35527236	E074	4502

rs4859365