SNP Detail Info-rs4891112

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G==0312 (9374/29960,GnomAD)
G==0369 (10763/29118,TOPMED)
G==0324 (1621/5008,1000G)
G==0212 (816/3854,ALSPAC)
G==0213 (789/3708,TWINSUK)

Position: chr18:76046148 (GRCh38.p7) (18q23)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 7 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 18	NC_000018.10:g.76046148G>A
GRCh37.p13 chr 18	NC_000018.9:g.73758103G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.607	A=0.393
1000Genomes	American	Sub	694	G=0.230	A=0.770
1000Genomes	East Asian	Sub	1008	G=0.286	A=0.714
1000Genomes	Europe	Sub	1006	G=0.193	A=0.807
1000Genomes	Global	Study-wide	5008	G=0.324	A=0.676
1000Genomes	South Asian	Sub	978	G=0.180	A=0.820
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.212	A=0.788
The Genome Aggregation Database	African	Sub	8716	G=0.539	A=0.461
The Genome Aggregation Database	American	Sub	838	G=0.230	A=0.770
The Genome Aggregation Database	East Asian	Sub	1618	G=0.286	A=0.714
The Genome Aggregation Database	Europe	Sub	18486	G=0.215	A=0.784
The Genome Aggregation Database	Global	Study-wide	29960	G=0.312	A=0.687
The Genome Aggregation Database	Other	Sub	302	G=0.140	A=0.860
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.369	A=0.630
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.213	A=0.787

PMID	Title	Author	Journal
24277619	ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.	Quillen EE	Am J Med Genet B Neuropsychiatr Genet

SNP ID	p-value	Traits	Study
rs4891112	0.000205	alcohol dependence	24277619

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr18	73762848	73763234	E071	4745
chr18	73752553	73753170	E081	-4933
chr18	73753975	73754047	E081	-4056
chr18	73764267	73764394	E081	6164
chr18	73764478	73764678	E081	6375
chr18	73762848	73763234	E082	4745
chr18	73763324	73764158	E082	5221

rs4891112