rs4895846

Homo sapiens
T>C
LAMA2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0494 (14751/29850,GnomAD)
C=0436 (12722/29118,TOPMED)
T==0454 (2276/5008,1000G)
T==0408 (1571/3854,ALSPAC)
T==0414 (1536/3708,TWINSUK)
chr6:129063222 (GRCh38.p7) (6q22.33)
AD
GWASdb2
1   publication(s)
See rs on genome
16 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.129063222T>C
GRCh37.p13 chr 6NC_000006.11:g.129384367T>C
LAMA2 RefSeqGene LRG_409

Gene: LAMA2, laminin subunit alpha 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LAMA2 transcript variant 1NM_000426.3:c.N/AIntron Variant
LAMA2 transcript variant 2NM_001079823.1:c.N/AIntron Variant
LAMA2 transcript variant X1XM_005266981.3:c.N/AIntron Variant
LAMA2 transcript variant X3XM_005266982.3:c.N/AIntron Variant
LAMA2 transcript variant X2XM_011535820.2:c.N/AIntron Variant
LAMA2 transcript variant X4XM_017010851.1:c.N/AIntron Variant
LAMA2 transcript variant X6XM_017010853.1:c.N/AIntron Variant
LAMA2 transcript variant X5XM_017010852.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.814C=0.186
1000GenomesAmericanSub694T=0.330C=0.670
1000GenomesEast AsianSub1008T=0.168C=0.832
1000GenomesEuropeSub1006T=0.435C=0.565
1000GenomesGlobalStudy-wide5008T=0.454C=0.546
1000GenomesSouth AsianSub978T=0.370C=0.630
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.408C=0.592
The Genome Aggregation DatabaseAfricanSub8706T=0.767C=0.233
The Genome Aggregation DatabaseAmericanSub834T=0.290C=0.710
The Genome Aggregation DatabaseEast AsianSub1612T=0.185C=0.815
The Genome Aggregation DatabaseEuropeSub18400T=0.400C=0.599
The Genome Aggregation DatabaseGlobalStudy-wide29850T=0.494C=0.505
The Genome Aggregation DatabaseOtherSub298T=0.550C=0.450
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.563C=0.436
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.414C=0.586
PMID Title Author Journal
19581569Genome-wide association study of alcohol dependence.Treutlein JArch Gen Psychiatry

P-Value

SNP ID p-value Traits Study
rs48958468.71E-05alcohol dependence19581569

eQTL of rs4895846 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4895846 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6129415073129415166E06830706
chr6129426300129426580E06841933
chr6129415073129415166E06930706
chr6129415230129415702E06930863
chr6129426300129426580E06941933
chr6129415073129415166E07130706
chr6129415230129415702E07130863
chr6129426053129426167E07141686
chr6129426300129426580E07141933
chr6129425281129426012E07340914
chr6129426053129426167E07341686
chr6129426300129426580E07341933
chr6129426053129426167E07441686
chr6129426300129426580E07441933
chr6129346564129346614E081-37753
chr6129346815129346927E081-37440