rs4901286

Homo sapiens
G>A
GPR137C : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0132 (3964/29958,GnomAD)
A=0129 (3765/29118,TOPMED)
A=0086 (433/5008,1000G)
A=0155 (598/3854,ALSPAC)
A=0156 (578/3708,TWINSUK)
chr14:52579883 (GRCh38.p7) (14q22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
34 Enhancers around
34 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.52579883G>A
GRCh37.p13 chr 14NC_000014.8:g.53046601G>A

Gene: GPR137C, G protein-coupled receptor 137C(plus strand)

Molecule type Change Amino acid[Codon] SO Term
GPR137C transcript variant 2NM_001099652.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.902A=0.098
1000GenomesAmericanSub694G=0.860A=0.140
1000GenomesEast AsianSub1008G=0.990A=0.010
1000GenomesEuropeSub1006G=0.860A=0.140
1000GenomesGlobalStudy-wide5008G=0.914A=0.086
1000GenomesSouth AsianSub978G=0.940A=0.060
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.845A=0.155
The Genome Aggregation DatabaseAfricanSub8728G=0.878A=0.122
The Genome Aggregation DatabaseAmericanSub838G=0.850A=0.150
The Genome Aggregation DatabaseEast AsianSub1620G=0.994A=0.006
The Genome Aggregation DatabaseEuropeSub18470G=0.853A=0.146
The Genome Aggregation DatabaseGlobalStudy-wide29958G=0.867A=0.132
The Genome Aggregation DatabaseOtherSub302G=0.830A=0.170
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.870A=0.129
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.844A=0.156
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs49012860.000329alcohol dependence20201924

eQTL of rs4901286 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4901286 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr145301663353016687E067-29914
chr145301689653016949E067-29652
chr145301234553012632E068-33969
chr145301267453012745E068-33856
chr145306893353069029E06822332
chr145306903153069162E06822430
chr145301702853017123E069-29478
chr145301714553017345E069-29256
chr145301382053013988E070-32613
chr145301702853017123E071-29478
chr145301714553017345E071-29256
chr145301234553012632E072-33969
chr145301267453012745E072-33856
chr145301313753013658E072-32943
chr145301702853017123E072-29478
chr145301234553012632E073-33969
chr145301267453012745E073-33856
chr145301313753013658E073-32943
chr145301702853017123E073-29478
chr145301714553017345E073-29256
chr145305649553056576E0739894
chr145301313753013658E074-32943
chr145301382053013988E074-32613
chr145301714553017345E074-29256
chr145301740753017457E074-29144
chr145301755653017632E074-28969
chr145301663353016687E081-29914
chr145301689653016949E081-29652
chr145301702853017123E081-29478
chr145301714553017345E081-29256
chr145301740753017457E081-29144
chr145301638453016477E082-30124
chr145301663353016687E082-29914
chr145301689653016949E082-29652










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr145301812153021412E067-25189
chr145302143353021571E067-25030
chr145302159353021738E067-24863
chr145302178053021909E067-24692
chr145301812153021412E068-25189
chr145302143353021571E068-25030
chr145302159353021738E068-24863
chr145302178053021909E068-24692
chr145301812153021412E069-25189
chr145302143353021571E069-25030
chr145302159353021738E069-24863
chr145302178053021909E069-24692
chr145301812153021412E070-25189
chr145302143353021571E070-25030
chr145302159353021738E070-24863
chr145302178053021909E070-24692
chr145301812153021412E071-25189
chr145301812153021412E072-25189
chr145302143353021571E072-25030
chr145302159353021738E072-24863
chr145302178053021909E072-24692
chr145301812153021412E073-25189
chr145302143353021571E073-25030
chr145302159353021738E073-24863
chr145302178053021909E073-24692
chr145301812153021412E074-25189
chr145301812153021412E081-25189
chr145302143353021571E081-25030
chr145302159353021738E081-24863
chr145302178053021909E081-24692
chr145301812153021412E082-25189
chr145302143353021571E082-25030
chr145302159353021738E082-24863
chr145302178053021909E082-24692