rs4903705

Homo sapiens
C>T
NRXN3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0187 (5600/29950,GnomAD)
T=0166 (4842/29118,TOPMED)
T=0163 (814/5008,1000G)
T=0202 (779/3854,ALSPAC)
T=0201 (744/3708,TWINSUK)
chr14:78089598 (GRCh38.p7) (14q24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
68 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.78089598C>T
GRCh37.p13 chr 14NC_000014.8:g.78555941C>T

Gene: NRXN3, neurexin 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
NRXN3 transcript variant 3NM_001105250.2:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant 4NM_001272020.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant 1NM_004796.5:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant 2NM_138970.4:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant 5NR_073546.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant 6NR_073547.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X2XM_011537364.2:c.N/AIntron Variant
NRXN3 transcript variant X3XM_017021790.1:c.N/AIntron Variant
NRXN3 transcript variant X4XM_017021791.1:c.N/AIntron Variant
NRXN3 transcript variant X6XM_005268218.2:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X7XM_006720322.2:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X21XM_006720323.2:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X1XM_011537363.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X5XM_011537365.2:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X9XM_011537366.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X15XM_011537367.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X19XM_011537368.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X20XM_011537369.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X21XM_011537370.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X25XM_011537371.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X26XM_011537372.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X31XM_011537373.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X44XM_011537377.2:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X8XM_017021792.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X10XM_017021793.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X11XM_017021794.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X12XM_017021795.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X13XM_017021796.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X13XM_017021797.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X14XM_017021798.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X17XM_017021799.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X22XM_017021800.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X23XM_017021801.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X24XM_017021802.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X27XM_017021803.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X28XM_017021804.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X29XM_017021805.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X30XM_017021806.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X30XM_017021807.1:c.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X32XR_001750599.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X33XR_001750600.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X34XR_001750601.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X35XR_001750602.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X36XR_001750603.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X37XR_001750604.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X38XR_001750605.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X39XR_001750606.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X40XR_001750607.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X41XR_001750608.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X42XR_001750609.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X44XR_001750610.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X45XR_943561.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X47XR_943562.1:n.N/AGenic Upstream Transcript Variant
NRXN3 transcript variant X46XR_943563.2:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.865T=0.135
1000GenomesAmericanSub694C=0.880T=0.120
1000GenomesEast AsianSub1008C=0.859T=0.141
1000GenomesEuropeSub1006C=0.786T=0.214
1000GenomesGlobalStudy-wide5008C=0.837T=0.163
1000GenomesSouth AsianSub978C=0.800T=0.200
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.798T=0.202
The Genome Aggregation DatabaseAfricanSub8720C=0.852T=0.148
The Genome Aggregation DatabaseAmericanSub836C=0.880T=0.120
The Genome Aggregation DatabaseEast AsianSub1616C=0.886T=0.114
The Genome Aggregation DatabaseEuropeSub18476C=0.786T=0.213
The Genome Aggregation DatabaseGlobalStudy-wide29950C=0.813T=0.187
The Genome Aggregation DatabaseOtherSub302C=0.740T=0.260
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.833T=0.166
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.799T=0.201
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs49037050.00052alcohol dependence20201924

eQTL of rs4903705 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4903705 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr147851259978512698E067-43243
chr147851281978513073E067-42868
chr147854100778541277E067-14664
chr147854154578541632E067-14309
chr147856342478563484E0677483
chr147856375878563894E0677817
chr147859771678597815E06741775
chr147859808978598345E06742148
chr147859855078598647E06742609
chr147854100778541277E068-14664
chr147854154578541632E068-14309
chr147854198178542057E068-13884
chr147859808978598345E06842148
chr147859855078598647E06842609
chr147851456278514774E069-41167
chr147854100778541277E069-14664
chr147854154578541632E069-14309
chr147856342478563484E0697483
chr147856375878563894E0697817
chr147859771678597815E06941775
chr147859808978598345E06942148
chr147854024578540285E070-15656
chr147854060778540695E070-15246
chr147854100778541277E070-14664
chr147854154578541632E070-14309
chr147854198178542057E070-13884
chr147854235178542444E070-13497
chr147858894478589309E07033003
chr147858935778589425E07033416
chr147851259978512698E071-43243
chr147851281978513073E071-42868
chr147854060778540695E071-15246
chr147854154578541632E071-14309
chr147854198178542057E071-13884
chr147854235178542444E071-13497
chr147856342478563484E0717483
chr147856375878563894E0717817
chr147859808978598345E07142148
chr147859855078598647E07142609
chr147851259978512698E072-43243
chr147854100778541277E072-14664
chr147854154578541632E072-14309
chr147854198178542057E072-13884
chr147855681678556866E072875
chr147856482478564927E0728883
chr147859771678597815E07241775
chr147859808978598345E07242148
chr147859808978598345E07342148
chr147859855078598647E07342609
chr147851281978513073E074-42868
chr147854100778541277E074-14664
chr147854154578541632E074-14309
chr147854198178542057E074-13884
chr147854235178542444E074-13497
chr147855681678556866E074875
chr147856342478563484E0747483
chr147856375878563894E0747817
chr147859771678597815E07441775
chr147859808978598345E07442148
chr147859855078598647E07442609
chr147854154578541632E081-14309
chr147854198178542057E081-13884
chr147854235178542444E081-13497
chr147858846078588514E08132519
chr147858894478589309E08133003
chr147858935778589425E08133416
chr147858955178589601E08133610
chr147858968778589764E08133746