rs4927081

Homo sapiens
T>C
SSBP3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0354 (10582/29872,GnomAD)
T==0350 (10204/29118,TOPMED)
T==0386 (1935/5008,1000G)
T==0310 (1195/3854,ALSPAC)
T==0307 (1139/3708,TWINSUK)
chr1:54290669 (GRCh38.p7) (1p32.3)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.54290669T>C
GRCh37.p13 chr 1NC_000001.10:g.54756342T>C

Gene: SSBP3, single stranded DNA binding protein 3(minus strand)

Molecule type Change Amino acid[Codon] SO Term
SSBP3 transcript variant 3NM_001009955.3:c.N/AIntron Variant
SSBP3 transcript variant 2NM_018070.4:c.N/AIntron Variant
SSBP3 transcript variant 1NM_145716.3:c.N/AIntron Variant
SSBP3 transcript variant X2XM_006710545.3:c.N/AIntron Variant
SSBP3 transcript variant X1XM_017000897.1:c.N/AIntron Variant
SSBP3 transcript variant X3XM_017000898.1:c.N/AIntron Variant
SSBP3 transcript variant X4XM_017000899.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.421C=0.579
1000GenomesAmericanSub694T=0.470C=0.530
1000GenomesEast AsianSub1008T=0.262C=0.738
1000GenomesEuropeSub1006T=0.342C=0.658
1000GenomesGlobalStudy-wide5008T=0.386C=0.614
1000GenomesSouth AsianSub978T=0.450C=0.550
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.310C=0.690
The Genome Aggregation DatabaseAfricanSub8696T=0.408C=0.592
The Genome Aggregation DatabaseAmericanSub838T=0.470C=0.530
The Genome Aggregation DatabaseEast AsianSub1616T=0.207C=0.793
The Genome Aggregation DatabaseEuropeSub18422T=0.337C=0.662
The Genome Aggregation DatabaseGlobalStudy-wide29872T=0.354C=0.645
The Genome Aggregation DatabaseOtherSub300T=0.320C=0.680
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.350C=0.649
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.307C=0.693
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs49270810.000581alcohol dependence20201924

eQTL of rs4927081 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4927081 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr15471124754711615E067-44727
chr15471167854711768E067-44574
chr15472245954723066E067-33276
chr15472307754723216E067-33126
chr15472324854723288E067-33054
chr15472341554723666E067-32676
chr15473421654734314E067-22028
chr15473440754734526E067-21816
chr15473467354734956E067-21386
chr15473852554739794E067-16548
chr15473987554740121E067-16221
chr15474019554740340E067-16002
chr15474035754740445E067-15897
chr15474045054740671E067-15671
chr15474075654740893E067-15449
chr15474089854741510E067-14832
chr15474173954741792E067-14550
chr15474183354742027E067-14315
chr15474234254742516E067-13826
chr15474260454742755E067-13587
chr15474282054744081E067-12261
chr15474416354744229E067-12113
chr15474427854744337E067-12005
chr15474464954745175E067-11167
chr15474530254745358E067-10984
chr15474565854745709E067-10633
chr15474600054746044E067-10298
chr15474625654746689E067-9653
chr15474678554746875E067-9467
chr15474720154747249E067-9093
chr15474726854747439E067-8903
chr15475147154751962E067-4380
chr15475208654752148E067-4194
chr15475239254752458E067-3884
chr15475246754752528E067-3814
chr15475254154752591E067-3751
chr15475268354753791E067-2551
chr15475383054753897E067-2445
chr15475398754754120E067-2222
chr15475474654755060E067-1282
chr15475513554755256E067-1086
chr15475530454755436E067-906
chr15475553254755583E067-759
chr15475568454755733E067-609
chr15475591854756940E0670
chr15475700054757050E067658
chr15475709654757600E067754
chr15475765254757724E0671310
chr15475780254757896E0671460
chr15475804354758124E0671701
chr15475827354758313E0671931
chr15475834454758407E0672002
chr15475856354758659E0672221
chr15475920254759412E0672860
chr15476067654760842E0674334
chr15476230854762381E0675966
chr15476286154762953E0676519
chr15476342554763680E0677083
chr15476368354765033E0677341
chr15476534054765504E0678998
chr15476551854765664E0679176
chr15476609254766152E0679750
chr15476624254766358E0679900
chr15476722254767288E06710880
chr15476742154767508E06711079
chr15476756154767648E06711219
chr15476838254768504E06712040
chr15476860454768860E06712262
chr15476888854768988E06712546
chr15476899654769286E06712654
chr15476969554769771E06713353
chr15477024554770424E06713903
chr15477044154770491E06714099
chr15477151654771566E06715174
chr15477184254771916E06715500
chr15477193554772200E06715593
chr15477463554774881E06718293
chr15477506754776099E06718725
chr15477621954776331E06719877
chr15477636454777324E06720022
chr15477732754777557E06720985
chr15477762254777688E06721280
chr15477788754777966E06721545
chr15477829654779099E06721954
chr15477925154779408E06722909
chr15477974554779863E06723403
chr15477995354780308E06723611
chr15478033354781087E06723991
chr15478891054789590E06732568
chr15478966254791284E06733320
chr15479141054791782E06735068
chr15479179754792103E06735455
chr15479214154792198E06735799
chr15479219954792280E06735857
chr15479228354792852E06735941
chr15479304154793178E06736699
chr15479321554794247E06736873
chr15479427754794343E06737935
chr15479440554794526E06738063
chr15479489354794949E06738551
chr15479505954795239E06738717
chr15479524454795733E06738902
chr15479656454796614E06740222
chr15479673454796801E06740392
chr15479685054797431E06740508
chr15479754954798156E06741207
chr15479818654799117E06741844
chr15479915354799268E06742811
chr15480014254800362E06743800
chr15480060254801979E06744260
chr15480571754805831E06749375
chr15480593554806043E06749593
chr15471124754711615E068-44727
chr15471167854711768E068-44574
chr15472245954723066E068-33276
chr15472307754723216E068-33126
chr15472582854726155E068-30187
chr15472625454726336E068-30006
chr15473396854734070E068-22272
chr15473421654734314E068-22028
chr15473440754734526E068-21816
chr15473467354734956E068-21386
chr15473706254737227E068-19115
chr15473770954737759E068-18583
chr15473785754738139E068-18203
chr15473818654738371E068-17971
chr15473852554739794E068-16548
chr15473987554740121E068-16221
chr15474019554740340E068-16002
chr15474035754740445E068-15897
chr15474045054740671E068-15671
chr15474075654740893E068-15449
chr15474089854741510E068-14832
chr15474173954741792E068-14550
chr15474183354742027E068-14315
chr15474234254742516E068-13826
chr15474260454742755E068-13587
chr15474282054744081E068-12261
chr15474464954745175E068-11167
chr15474530254745358E068-10984
chr15474678554746875E068-9467
chr15474720154747249E068-9093
chr15474726854747439E068-8903
chr15475147154751962E068-4380
chr15475208654752148E068-4194
chr15475239254752458E068-3884
chr15475246754752528E068-3814
chr15475254154752591E068-3751
chr15475268354753791E068-2551
chr15475383054753897E068-2445
chr15475398754754120E068-2222
chr15475474654755060E068-1282
chr15475513554755256E068-1086
chr15475530454755436E068-906
chr15475553254755583E068-759
chr15475568454755733E068-609
chr15475591854756940E0680
chr15475700054757050E068658
chr15475709654757600E068754
chr15475765254757724E0681310
chr15475780254757896E0681460
chr15475804354758124E0681701
chr15475827354758313E0681931
chr15475834454758407E0682002
chr15475856354758659E0682221
chr15475920254759412E0682860
chr15476173754761781E0685395
chr15476230854762381E0685966
chr15476286154762953E0686519
chr15476342554763680E0687083
chr15476368354765033E0687341
chr15476534054765504E0688998
chr15476551854765664E0689176
chr15476609254766152E0689750
chr15476624254766358E0689900
chr15476722254767288E06810880
chr15476742154767508E06811079
chr15476756154767648E06811219
chr15476838254768504E06812040
chr15476860454768860E06812262
chr15476888854768988E06812546
chr15476899654769286E06812654
chr15476969554769771E06813353
chr15477024554770424E06813903
chr15477044154770491E06814099
chr15477151654771566E06815174
chr15477463554774881E06818293
chr15477506754776099E06818725
chr15477621954776331E06819877
chr15477636454777324E06820022
chr15477732754777557E06820985
chr15477762254777688E06821280
chr15477829654779099E06821954
chr15478033354781087E06823991
chr15478624654786306E06829904
chr15478638954786568E06830047
chr15478891054789590E06832568
chr15478966254791284E06833320
chr15479141054791782E06835068
chr15479179754792103E06835455
chr15479214154792198E06835799
chr15479219954792280E06835857
chr15479228354792852E06835941
chr15479304154793178E06836699
chr15479321554794247E06836873
chr15479427754794343E06837935
chr15479440554794526E06838063
chr15479489354794949E06838551
chr15479505954795239E06838717
chr15479524454795733E06838902
chr15479656454796614E06840222
chr15479673454796801E06840392
chr15479685054797431E06840508
chr15479754954798156E06841207
chr15479818654799117E06841844
chr15479915354799268E06842811
chr15480014254800362E06843800
chr15480060254801979E06844260
chr15480228054802579E06845938
chr15480258454802972E06846242
chr15471124754711615E069-44727
chr15471167854711768E069-44574
chr15471200654712504E069-43838
chr15471255254712631E069-43711
chr15471361154713870E069-42472
chr15472237554722444E069-33898
chr15472245954723066E069-33276
chr15472307754723216E069-33126
chr15472324854723288E069-33054
chr15472582854726155E069-30187
chr15472625454726336E069-30006
chr15472675954726804E069-29538
chr15472686654726946E069-29396
chr15472698054727030E069-29312
chr15473396854734070E069-22272
chr15473421654734314E069-22028
chr15473440754734526E069-21816
chr15473706254737227E069-19115
chr15473770954737759E069-18583
chr15473785754738139E069-18203
chr15473818654738371E069-17971
chr15473852554739794E069-16548
chr15473987554740121E069-16221
chr15474019554740340E069-16002
chr15474035754740445E069-15897
chr15474045054740671E069-15671
chr15474075654740893E069-15449
chr15474089854741510E069-14832
chr15474173954741792E069-14550
chr15474183354742027E069-14315
chr15474234254742516E069-13826
chr15474260454742755E069-13587
chr15474282054744081E069-12261
chr15474416354744229E069-12113
chr15474427854744337E069-12005
chr15474625654746689E069-9653
chr15474678554746875E069-9467
chr15474720154747249E069-9093
chr15474726854747439E069-8903
chr15474776754748086E069-8256
chr15474821854748303E069-8039
chr15474834054748413E069-7929
chr15474889454749194E069-7148
chr15474946354749513E069-6829
chr15474952654749636E069-6706
chr15475208654752148E069-4194
chr15475239254752458E069-3884
chr15475246754752528E069-3814
chr15475254154752591E069-3751
chr15475268354753791E069-2551
chr15475383054753897E069-2445
chr15475398754754120E069-2222
chr15475441754754457E069-1885
chr15475474654755060E069-1282
chr15475513554755256E069-1086
chr15475530454755436E069-906
chr15475553254755583E069-759
chr15475568454755733E069-609
chr15475591854756940E0690
chr15475700054757050E069658
chr15475709654757600E069754
chr15475765254757724E0691310
chr15475780254757896E0691460
chr15475804354758124E0691701
chr15475827354758313E0691931
chr15475834454758407E0692002
chr15475856354758659E0692221
chr15475920254759412E0692860
chr15475988354759927E0693541
chr15476031454760364E0693972
chr15476067654760842E0694334
chr15476086954760956E0694527
chr15476098354761052E0694641
chr15476119954761249E0694857
chr15476173754761781E0695395
chr15476230854762381E0695966
chr15476286154762953E0696519
chr15476342554763680E0697083
chr15476368354765033E0697341
chr15476534054765504E0698998
chr15476551854765664E0699176
chr15476609254766152E0699750
chr15476624254766358E0699900
chr15476722254767288E06910880
chr15476742154767508E06911079
chr15476838254768504E06912040
chr15476860454768860E06912262
chr15476888854768988E06912546
chr15476899654769286E06912654
chr15476969554769771E06913353
chr15477024554770424E06913903
chr15477044154770491E06914099
chr15477463554774881E06918293
chr15477506754776099E06918725
chr15477621954776331E06919877
chr15477636454777324E06920022
chr15477732754777557E06920985
chr15477762254777688E06921280
chr15477788754777966E06921545
chr15477829654779099E06921954
chr15477995354780308E06923611
chr15478033354781087E06923991
chr15478891054789590E06932568
chr15478966254791284E06933320
chr15479141054791782E06935068
chr15479179754792103E06935455
chr15479214154792198E06935799
chr15479219954792280E06935857
chr15479228354792852E06935941
chr15479304154793178E06936699
chr15479321554794247E06936873
chr15479427754794343E06937935
chr15479440554794526E06938063
chr15479489354794949E06938551
chr15479505954795239E06938717
chr15479524454795733E06938902
chr15479656454796614E06940222
chr15479673454796801E06940392
chr15479685054797431E06940508
chr15479754954798156E06941207
chr15479818654799117E06941844
chr15479915354799268E06942811
chr15480014254800362E06943800
chr15480060254801979E06944260
chr15480228054802579E06945938
chr15480258454802972E06946242
chr15480593554806043E06949593
chr15472237554722444E070-33898
chr15472245954723066E070-33276
chr15472307754723216E070-33126
chr15472324854723288E070-33054
chr15472341554723666E070-32676
chr15472504754725138E070-31204
chr15472541454725801E070-30541
chr15472582854726155E070-30187
chr15472625454726336E070-30006
chr15473639854736470E070-19872
chr15473706254737227E070-19115
chr15473852554739794E070-16548
chr15473987554740121E070-16221
chr15474019554740340E070-16002
chr15474035754740445E070-15897
chr15474089854741510E070-14832
chr15475208654752148E070-4194
chr15475239254752458E070-3884
chr15475246754752528E070-3814
chr15475254154752591E070-3751
chr15475268354753791E070-2551
chr15475383054753897E070-2445
chr15475398754754120E070-2222
chr15475700054757050E070658
chr15475709654757600E070754
chr15475765254757724E0701310
chr15475780254757896E0701460
chr15475804354758124E0701701
chr15475827354758313E0701931
chr15475834454758407E0702002
chr15476342554763680E0707083
chr15476368354765033E0707341
chr15476534054765504E0708998
chr15476551854765664E0709176
chr15476609254766152E0709750
chr15476624254766358E0709900
chr15476722254767288E07010880
chr15476742154767508E07011079
chr15476756154767648E07011219
chr15476838254768504E07012040
chr15476860454768860E07012262
chr15476888854768988E07012546
chr15476899654769286E07012654
chr15476969554769771E07013353
chr15477506754776099E07018725
chr15477621954776331E07019877
chr15477636454777324E07020022
chr15477829654779099E07021954
chr15477925154779408E07022909
chr15477974554779863E07023403
chr15477995354780308E07023611
chr15478033354781087E07023991
chr15478150954781604E07025167
chr15478891054789590E07032568
chr15478966254791284E07033320
chr15479141054791782E07035068
chr15479179754792103E07035455
chr15479214154792198E07035799
chr15479219954792280E07035857
chr15479228354792852E07035941
chr15479304154793178E07036699
chr15479321554794247E07036873
chr15479427754794343E07037935
chr15479440554794526E07038063
chr15479489354794949E07038551
chr15479505954795239E07038717
chr15479524454795733E07038902
chr15479685054797431E07040508
chr15479754954798156E07041207
chr15479818654799117E07041844
chr15480060254801979E07044260
chr15471124754711615E071-44727
chr15471167854711768E071-44574
chr15471361154713870E071-42472
chr15471915954719695E071-36647
chr15471973354720329E071-36013
chr15472237554722444E071-33898
chr15472245954723066E071-33276
chr15472307754723216E071-33126
chr15472324854723288E071-33054
chr15473266754732943E071-23399
chr15473421654734314E071-22028
chr15473440754734526E071-21816
chr15473467354734956E071-21386
chr15473706254737227E071-19115
chr15473818654738371E071-17971
chr15473987554740121E071-16221
chr15474019554740340E071-16002
chr15474035754740445E071-15897
chr15474045054740671E071-15671
chr15474075654740893E071-15449
chr15474089854741510E071-14832
chr15474173954741792E071-14550
chr15474183354742027E071-14315
chr15474234254742516E071-13826
chr15474260454742755E071-13587
chr15474282054744081E071-12261
chr15474416354744229E071-12113
chr15474427854744337E071-12005
chr15474625654746689E071-9653
chr15474678554746875E071-9467
chr15474720154747249E071-9093
chr15474726854747439E071-8903
chr15474776754748086E071-8256
chr15474821854748303E071-8039
chr15474834054748413E071-7929
chr15475208654752148E071-4194
chr15475239254752458E071-3884
chr15475246754752528E071-3814
chr15475254154752591E071-3751
chr15475268354753791E071-2551
chr15475383054753897E071-2445
chr15475398754754120E071-2222
chr15475441754754457E071-1885
chr15475474654755060E071-1282
chr15475513554755256E071-1086
chr15475530454755436E071-906
chr15475553254755583E071-759
chr15475568454755733E071-609
chr15475591854756940E0710
chr15475700054757050E071658
chr15475709654757600E071754
chr15475765254757724E0711310
chr15475780254757896E0711460
chr15475804354758124E0711701
chr15475827354758313E0711931
chr15475834454758407E0712002
chr15475856354758659E0712221
chr15475920254759412E0712860
chr15476067654760842E0714334
chr15476086954760956E0714527
chr15476098354761052E0714641
chr15476119954761249E0714857
chr15476173754761781E0715395
chr15476230854762381E0715966
chr15476286154762953E0716519
chr15476342554763680E0717083
chr15476368354765033E0717341
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