rs4934119

Homo sapiens
C>G
LOC105378404 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0070 (2088/29844,GnomAD)
C==0097 (2851/29118,TOPMED)
C==0075 (378/5008,1000G)
C==0037 (142/3854,ALSPAC)
C==0042 (154/3708,TWINSUK)
chr10:85552569 (GRCh38.p7) (10q23.1)
ND
GWASdb2
1   publication(s)
See rs on genome
110 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.85552569C>G
GRCh37.p13 chr 10NC_000010.10:g.87312326C>G

Gene: LOC105378404, uncharacterized LOC105378404(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105378404 transcript variant X2XR_946157.2:n.N/AIntron Variant
LOC105378404 transcript variant X3XR_001747522.1:n.N/AGenic Downstream Transcript Variant
LOC105378404 transcript variant X4XR_001747523.1:n.N/AGenic Downstream Transcript Variant
LOC105378404 transcript variant X1XR_946156.2:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.163G=0.837
1000GenomesAmericanSub694C=0.060G=0.940
1000GenomesEast AsianSub1008C=0.032G=0.968
1000GenomesEuropeSub1006C=0.038G=0.962
1000GenomesGlobalStudy-wide5008C=0.075G=0.925
1000GenomesSouth AsianSub978C=0.050G=0.950
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.037G=0.963
The Genome Aggregation DatabaseAfricanSub8714C=0.152G=0.848
The Genome Aggregation DatabaseAmericanSub832C=0.060G=0.940
The Genome Aggregation DatabaseEast AsianSub1574C=0.018G=0.982
The Genome Aggregation DatabaseEuropeSub18422C=0.035G=0.964
The Genome Aggregation DatabaseGlobalStudy-wide29844C=0.070G=0.930
The Genome Aggregation DatabaseOtherSub302C=0.110G=0.890
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.097G=0.902
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.042G=0.958
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs49341190.000157nicotine dependence17158188

eQTL of rs4934119 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4934119 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr108727013287270188E067-42138
chr108730731187307530E067-4796
chr108730761987307753E067-4573
chr108730780087308130E067-4196
chr108735286287352902E06740536
chr108735303687353182E06740710
chr108735683287356990E06744506
chr108735702887357149E06744702
chr108735977687359849E06747450
chr108736014187360299E06747815
chr108736030187360462E06747975
chr108736077287360854E06748446
chr108732890787329042E06816581
chr108733004187330207E06817715
chr108735268987352757E06840363
chr108735286287352902E06840536
chr108735303687353182E06840710
chr108736030187360462E06847975
chr108736077287360854E06848446
chr108727042787270487E069-41839
chr108728684387286960E069-25366
chr108728699087287155E069-25171
chr108730761987307753E069-4573
chr108730780087308130E069-4196
chr108732841987328522E06916093
chr108732854887328598E06916222
chr108732890787329042E06916581
chr108735286287352902E06940536
chr108735303687353182E06940710
chr108735346387353544E06941137
chr108735358787353627E06941261
chr108735395687354312E06941630
chr108735434887354449E06942022
chr108735449287354543E06942166
chr108735456787354816E06942241
chr108735633687356386E06944010
chr108735644087356490E06944114
chr108735650187356551E06944175
chr108735683287356990E06944506
chr108735702887357149E06944702
chr108735977687359849E06947450
chr108736014187360299E06947815
chr108736030187360462E06947975
chr108736077287360854E06948446
chr108728362287283746E070-28580
chr108728384787284156E070-28170
chr108728422387284309E070-28017
chr108728436687284467E070-27859
chr108728626687286386E070-25940
chr108728656087286600E070-25726
chr108728684387286960E070-25366
chr108728699087287155E070-25171
chr108726799687268242E071-44084
chr108727042787270487E071-41839
chr108727055887270713E071-41613
chr108730731187307530E071-4796
chr108730761987307753E071-4573
chr108730780087308130E071-4196
chr108732890787329042E07116581
chr108733004187330207E07117715
chr108735303687353182E07140710
chr108735683287356990E07144506
chr108735702887357149E07144702
chr108735868787358737E07146361
chr108735888487358942E07146558
chr108735944087359490E07147114
chr108735977687359849E07147450
chr108736014187360299E07147815
chr108736030187360462E07147975
chr108736077287360854E07148446
chr108736129787361635E07148971
chr108730780087308130E072-4196
chr108730813187308402E072-3924
chr108732890787329042E07216581
chr108735268987352757E07240363
chr108735286287352902E07240536
chr108735303687353182E07240710
chr108735346387353544E07241137
chr108735358787353627E07241261
chr108735633687356386E07244010
chr108735644087356490E07244114
chr108735650187356551E07244175
chr108735683287356990E07244506
chr108735702887357149E07244702
chr108735888487358942E07246558
chr108735944087359490E07247114
chr108735977687359849E07247450
chr108736014187360299E07247815
chr108736030187360462E07247975
chr108736077287360854E07248446
chr108736129787361635E07248971
chr108730731187307530E073-4796
chr108730761987307753E073-4573
chr108730780087308130E073-4196
chr108735977687359849E07347450
chr108727013287270188E074-42138
chr108727042787270487E074-41839
chr108727055887270713E074-41613
chr108732890787329042E07416581
chr108735644087356490E07444114
chr108735650187356551E07444175
chr108735683287356990E07444506
chr108735702887357149E07444702
chr108735747387357533E07445147
chr108735888487358942E07446558
chr108735944087359490E07447114
chr108735977687359849E07447450
chr108736014187360299E07447815
chr108736030187360462E07447975
chr108736077287360854E07448446