rs4936173

Homo sapiens
C>T
OPCML : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0227 (6798/29922,GnomAD)
C==0217 (6341/29118,TOPMED)
C==0266 (1330/5008,1000G)
C==0232 (895/3854,ALSPAC)
C==0240 (891/3708,TWINSUK)
chr11:132622531 (GRCh38.p7) (11q25)
AD
GWASdb2
1   publication(s)
See rs on genome
108 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.132622531C>T
GRCh37.p13 chr 11NC_000011.9:g.132492426C>T
OPCML RefSeqGeneNG_012107.1:g.914978G>A

Gene: OPCML, opioid binding protein/cell adhesion molecule-like(minus strand)

Molecule type Change Amino acid[Codon] SO Term
OPCML transcript variant 2NM_001012393.2:c.N/AIntron Variant
OPCML transcript variant 3NM_001319103.1:c.N/AIntron Variant
OPCML transcript variant 4NM_001319104.1:c.N/AIntron Variant
OPCML transcript variant 5NM_001319105.1:c.N/AIntron Variant
OPCML transcript variant 6NM_001319106.1:c.N/AIntron Variant
OPCML transcript variant 1NM_002545.4:c.N/AIntron Variant
OPCML transcript variant X1XM_006718846.2:c.N/AIntron Variant
OPCML transcript variant X2XM_011542856.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.129T=0.871
1000GenomesAmericanSub694C=0.360T=0.640
1000GenomesEast AsianSub1008C=0.440T=0.560
1000GenomesEuropeSub1006C=0.233T=0.767
1000GenomesGlobalStudy-wide5008C=0.266T=0.734
1000GenomesSouth AsianSub978C=0.240T=0.760
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.232T=0.768
The Genome Aggregation DatabaseAfricanSub8718C=0.156T=0.844
The Genome Aggregation DatabaseAmericanSub836C=0.370T=0.630
The Genome Aggregation DatabaseEast AsianSub1612C=0.473T=0.527
The Genome Aggregation DatabaseEuropeSub18454C=0.231T=0.768
The Genome Aggregation DatabaseGlobalStudy-wide29922C=0.227T=0.772
The Genome Aggregation DatabaseOtherSub302C=0.310T=0.690
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.217T=0.782
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.240T=0.760
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs49361730.000373alcohol dependence21314694

eQTL of rs4936173 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs4936173 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr11132456477132456535E067-35891
chr11132456764132457109E067-35317
chr11132457243132457293E067-35133
chr11132457497132457622E067-34804
chr11132476217132476328E067-16098
chr11132476369132476445E067-15981
chr11132510500132510691E06718074
chr11132524748132524803E06732322
chr11132524820132524870E06732394
chr11132525278132525718E06732852
chr11132476217132476328E068-16098
chr11132476369132476445E068-15981
chr11132476522132476669E068-15757
chr11132476709132476789E068-15637
chr11132456477132456535E069-35891
chr11132456764132457109E069-35317
chr11132476217132476328E069-16098
chr11132476369132476445E069-15981
chr11132476522132476669E069-15757
chr11132476709132476789E069-15637
chr11132478097132478322E069-14104
chr11132456764132457109E070-35317
chr11132465287132465500E070-26926
chr11132465517132466063E070-26363
chr11132466106132466303E070-26123
chr11132466462132466576E070-25850
chr11132466815132466865E070-25561
chr11132502293132502372E0709867
chr11132502420132503082E0709994
chr11132509119132509179E07016693
chr11132509236132509316E07016810
chr11132509427132509550E07017001
chr11132514177132514233E07021751
chr11132514568132514627E07022142
chr11132514684132514769E07022258
chr11132514953132515003E07022527
chr11132515124132515222E07022698
chr11132456764132457109E071-35317
chr11132472373132472438E071-19988
chr11132472735132472785E071-19641
chr11132476830132476895E071-15531
chr11132478097132478322E071-14104
chr11132478836132478876E071-13550
chr11132456477132456535E072-35891
chr11132456764132457109E072-35317
chr11132457243132457293E072-35133
chr11132471678132472176E072-20250
chr11132472373132472438E072-19988
chr11132472735132472785E072-19641
chr11132478097132478322E072-14104
chr11132478836132478876E072-13550
chr11132496182132496757E0723756
chr11132502420132503082E0729994
chr11132456764132457109E073-35317
chr11132457243132457293E073-35133
chr11132457497132457622E073-34804
chr11132457717132457884E073-34542
chr11132457937132458010E073-34416
chr11132471678132472176E073-20250
chr11132456477132456535E074-35891
chr11132456764132457109E074-35317
chr11132457243132457293E074-35133
chr11132476217132476328E074-16098
chr11132476369132476445E074-15981
chr11132476522132476669E074-15757
chr11132476709132476789E074-15637
chr11132476830132476895E074-15531
chr11132478097132478322E074-14104
chr11132478836132478876E074-13550
chr11132496182132496757E0743756
chr11132465287132465500E081-26926
chr11132465517132466063E081-26363
chr11132466106132466303E081-26123
chr11132466462132466576E081-25850
chr11132466815132466865E081-25561
chr11132467298132467408E081-25018
chr11132471100132471150E081-21276
chr11132471678132472176E081-20250
chr11132472373132472438E081-19988
chr11132502420132503082E0819994
chr11132509236132509316E08116810
chr11132509427132509550E08117001
chr11132534896132534955E08142470
chr11132535028132535120E08142602
chr11132535172132535390E08142746
chr11132539794132540188E08147368
chr11132540780132540830E08148354
chr11132540874132541385E08148448
chr11132541468132541518E08149042
chr11132541540132541646E08149114
chr11132541877132542114E08149451
chr11132465287132465500E082-26926
chr11132465517132466063E082-26363
chr11132466106132466303E082-26123
chr11132466462132466576E082-25850
chr11132466815132466865E082-25561
chr11132467298132467408E082-25018
chr11132502420132503082E0829994
chr11132503216132503336E08210790
chr11132503436132503520E08211010
chr11132503564132503614E08211138
chr11132539374132539424E08246948
chr11132539794132540188E08247368
chr11132540780132540830E08248354
chr11132540874132541385E08248448
chr11132541468132541518E08249042
chr11132541540132541646E08249114
chr11132541877132542114E08249451