rs509276

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0236 (7072/29940,GnomAD)
A=0292 (8503/29118,TOPMED)
A=0228 (1141/5008,1000G)
A=0191 (735/3854,ALSPAC)
A=0194 (720/3708,TWINSUK)
chr9:110819079 (GRCh38.p7) (9q31.3)
AD
GWASdb2
2   publication(s)
See rs on genome
86 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.110819079G>A
GRCh37.p13 chr 9NC_000009.11:g.113581359G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.544A=0.456
1000GenomesAmericanSub694G=0.850A=0.150
1000GenomesEast AsianSub1008G=0.957A=0.043
1000GenomesEuropeSub1006G=0.777A=0.223
1000GenomesGlobalStudy-wide5008G=0.772A=0.228
1000GenomesSouth AsianSub978G=0.830A=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.809A=0.191
The Genome Aggregation DatabaseAfricanSub8710G=0.604A=0.396
The Genome Aggregation DatabaseAmericanSub836G=0.890A=0.110
The Genome Aggregation DatabaseEast AsianSub1620G=0.967A=0.033
The Genome Aggregation DatabaseEuropeSub18474G=0.817A=0.182
The Genome Aggregation DatabaseGlobalStudy-wide29940G=0.763A=0.236
The Genome Aggregation DatabaseOtherSub300G=0.650A=0.350
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.708A=0.292
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.806A=0.194
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res
26597164RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles.Webb ABMC Genomics

P-Value

SNP ID p-value Traits Study
rs5092760.000025alcohol dependence(early age of onset)20201924
rs5092760.0000253alcoholismpha002892
rs5092760.00014alcohol dependence20201924

eQTL of rs509276 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs509276 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr9113531771113531987E067-49372
chr9113532033113532268E067-49091
chr9113538242113538465E067-42894
chr9113538506113539147E067-42212
chr9113539203113539495E067-41864
chr9113539511113539728E067-41631
chr9113582672113582777E0671313
chr9113582825113582943E0671466
chr9113590976113591171E0679617
chr9113591254113591321E0679895
chr9113591362113591681E06710003
chr9113547876113547941E068-33418
chr9113590276113590441E0688917
chr9113531771113531987E069-49372
chr9113564602113565164E069-16195
chr9113582227113582277E069868
chr9113582672113582777E0691313
chr9113582825113582943E0691466
chr9113583428113583661E0692069
chr9113590976113591171E0699617
chr9113591254113591321E0699895
chr9113591362113591681E06910003
chr9113537322113537389E070-43970
chr9113537526113537634E070-43725
chr9113537966113538054E070-43305
chr9113538242113538465E070-42894
chr9113539958113540029E070-41330
chr9113540165113540348E070-41011
chr9113540382113540442E070-40917
chr9113531771113531987E071-49372
chr9113532033113532268E071-49091
chr9113538506113539147E071-42212
chr9113539203113539495E071-41864
chr9113539511113539728E071-41631
chr9113541151113541404E071-39955
chr9113541873113541932E071-39427
chr9113564602113565164E071-16195
chr9113565235113565398E071-15961
chr9113565630113565734E071-15625
chr9113570369113570501E071-10858
chr9113582227113582277E071868
chr9113582672113582777E0711313
chr9113590276113590441E0718917
chr9113590562113590940E0719203
chr9113590976113591171E0719617
chr9113591254113591321E0719895
chr9113591362113591681E07110003
chr9113539203113539495E072-41864
chr9113539511113539728E072-41631
chr9113539803113539909E072-41450
chr9113539958113540029E072-41330
chr9113540165113540348E072-41011
chr9113582227113582277E072868
chr9113582672113582777E0721313
chr9113582825113582943E0721466
chr9113583428113583661E0722069
chr9113590276113590441E0728917
chr9113590562113590940E0729203
chr9113594449113594514E07213090
chr9113594554113594689E07213195
chr9113531771113531987E074-49372
chr9113532033113532268E074-49091
chr9113537966113538054E074-43305
chr9113538131113538227E074-43132
chr9113538242113538465E074-42894
chr9113538506113539147E074-42212
chr9113539203113539495E074-41864
chr9113539511113539728E074-41631
chr9113540165113540348E074-41011
chr9113540774113540970E074-40389
chr9113562309113562367E074-18992
chr9113564602113565164E074-16195
chr9113570369113570501E074-10858
chr9113582227113582277E074868
chr9113582672113582777E0741313
chr9113582825113582943E0741466
chr9113583428113583661E0742069
chr9113590276113590441E0748917
chr9113590562113590940E0749203
chr9113593850113593910E07412491
chr9113537322113537389E081-43970
chr9113537966113538054E081-43305
chr9113538131113538227E081-43132
chr9113538242113538465E081-42894
chr9113564602113565164E081-16195
chr9113564602113565164E082-16195