rs526257

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0095 (2842/29898,GnomAD)
G==0107 (3115/29118,TOPMED)
G==0134 (670/5008,1000G)
G==0088 (340/3854,ALSPAC)
G==0091 (336/3708,TWINSUK)
chr11:124092093 (GRCh38.p7) (11q24.2)
ND
GWASdb2
1   publication(s)
See rs on genome
15 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.124092093G>A
GRCh37.p13 chr 11NC_000011.9:g.123962800G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.095A=0.905
1000GenomesAmericanSub694G=0.200A=0.800
1000GenomesEast AsianSub1008G=0.211A=0.789
1000GenomesEuropeSub1006G=0.089A=0.911
1000GenomesGlobalStudy-wide5008G=0.134A=0.866
1000GenomesSouth AsianSub978G=0.110A=0.890
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.088A=0.912
The Genome Aggregation DatabaseAfricanSub8726G=0.095A=0.905
The Genome Aggregation DatabaseAmericanSub838G=0.200A=0.800
The Genome Aggregation DatabaseEast AsianSub1612G=0.235A=0.765
The Genome Aggregation DatabaseEuropeSub18420G=0.078A=0.921
The Genome Aggregation DatabaseGlobalStudy-wide29898G=0.095A=0.904
The Genome Aggregation DatabaseOtherSub302G=0.070A=0.930
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.107A=0.893
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.091A=0.909
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs5262570.000498nicotine dependence17158188

eQTL of rs526257 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs526257 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr11123940864123940941E068-21859
chr11123941055123941139E068-21661
chr11123941292123941369E068-21431
chr11123987705123987764E06824905
chr11123939453123939969E070-22831
chr11123984472123984682E07121672
chr11123984724123984968E07121924
chr11123957837123957981E072-4819
chr11123940864123940941E081-21859
chr11123956096123957050E081-5750
chr11123961697123962118E081-682
chr11123964147123964385E0811347
chr11123964518123964693E0811718
chr11123939453123939969E082-22831
chr11123956096123957050E082-5750






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr11123946528123947549E067-15251
chr11123985435123987315E06722635
chr11123946528123947549E068-15251
chr11123985435123987315E06822635
chr11123946528123947549E069-15251
chr11123985435123987315E06922635
chr11123946528123947549E070-15251
chr11123985435123987315E07022635
chr11123946528123947549E071-15251
chr11123985435123987315E07122635
chr11123946528123947549E072-15251
chr11123985435123987315E07222635
chr11123946528123947549E073-15251
chr11123985435123987315E07322635
chr11123946528123947549E074-15251
chr11123985435123987315E07422635
chr11123985435123987315E08122635
chr11123946528123947549E082-15251
chr11123985435123987315E08222635