rs533682

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0374 (11216/29936,GnomAD)
C=0464 (13532/29118,TOPMED)
T==0474 (2376/5008,1000G)
C=0213 (819/3854,ALSPAC)
C=0213 (791/3708,TWINSUK)
chr18:7491480 (GRCh38.p7) (18p11.23)
ND
GWASdb2
1   publication(s)
See rs on genome
42 Enhancers around
15 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.7491480T>C
GRCh37.p13 chr 18NC_000018.9:g.7491478T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.170C=0.830
1000GenomesAmericanSub694T=0.680C=0.320
1000GenomesEast AsianSub1008T=0.380C=0.620
1000GenomesEuropeSub1006T=0.794C=0.206
1000GenomesGlobalStudy-wide5008T=0.474C=0.526
1000GenomesSouth AsianSub978T=0.510C=0.490
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.787C=0.213
The Genome Aggregation DatabaseAfricanSub8714T=0.260C=0.740
The Genome Aggregation DatabaseAmericanSub838T=0.700C=0.300
The Genome Aggregation DatabaseEast AsianSub1610T=0.352C=0.648
The Genome Aggregation DatabaseEuropeSub18474T=0.816C=0.183
The Genome Aggregation DatabaseGlobalStudy-wide29936T=0.625C=0.374
The Genome Aggregation DatabaseOtherSub300T=0.700C=0.300
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.535C=0.464
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.787C=0.213
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs5336824.24E-05alcohol and nictotine co-dependence20158304

eQTL of rs533682 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs533682 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1874589787459133E067-32345
chr1874594617459511E067-31967
chr1874614197461485E067-29993
chr1874589787459133E068-32345
chr1874594617459511E068-31967
chr1874614197461485E068-29993
chr1875123367512398E06820858
chr1875124417512651E06820963
chr1874589787459133E069-32345
chr1874594617459511E069-31967
chr1874559847456032E070-35446
chr1874565157456686E070-34792
chr1874568437456964E070-34514
chr1874570807457160E070-34318
chr1874572547457595E070-33883
chr1874589787459133E070-32345
chr1874594617459511E070-31967
chr1874673757467468E070-24010
chr1875123367512398E07020858
chr1875124417512651E07020963
chr1875128147512891E07021336
chr1874589787459133E071-32345
chr1874594617459511E071-31967
chr1874614197461485E071-29993
chr1874589787459133E072-32345
chr1874594617459511E072-31967
chr1874614197461485E072-29993
chr1874594617459511E073-31967
chr1874589787459133E074-32345
chr1874594617459511E074-31967
chr1874614197461485E074-29993
chr1874818527483498E074-7980
chr1874836977483785E074-7693
chr1874598187460170E081-31308
chr1874614197461485E081-29993
chr1875123367512398E08120858
chr1875124417512651E08120963
chr1875128147512891E08121336
chr1875131757513265E08121697
chr1874565157456686E082-34792
chr1874594617459511E082-31967
chr1874598187460170E082-31308










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1874602197460786E067-30692
chr1874608327460999E067-30479
chr1874602197460786E068-30692
chr1874608327460999E068-30479
chr1874602197460786E069-30692
chr1874608327460999E069-30479
chr1874602197460786E070-30692
chr1874602197460786E071-30692
chr1874608327460999E071-30479
chr1874602197460786E072-30692
chr1874608327460999E072-30479
chr1874602197460786E073-30692
chr1874608327460999E073-30479
chr1874602197460786E074-30692
chr1874608327460999E074-30479