rs58335266

Homo sapiens
G>A
HSPE1-MOB4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0328 (3077/9392,GnomAD)
G==0403 (2018/5008,1000G)
chr2:197505616 (GRCh38.p7) (2q33.1)
AD
GWASCatalog
1   publication(s)
See rs on genome

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.197505616G>A
GRCh37.p13 chr 2NC_000002.11:g.198370340G>A

Gene: HSPE1-MOB4, HSPE1-MOB4 readthrough(plus strand)

Molecule type Change Amino acid[Codon] SO Term
HSPE1-MOB4 transcriptNM_001202485.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.397A=0.603
1000GenomesAmericanSub694G=0.410A=0.590
1000GenomesEast AsianSub1008G=0.531A=0.469
1000GenomesEuropeSub1006G=0.304A=0.696
1000GenomesGlobalStudy-wide5008G=0.403A=0.597
1000GenomesSouth AsianSub978G=0.380A=0.620
The Genome Aggregation DatabaseAfricanSub2936G=0.643A=0.357
The Genome Aggregation DatabaseAmericanSub130G=0.620A=0.380
The Genome Aggregation DatabaseEast AsianSub862G=0.550A=0.450
The Genome Aggregation DatabaseEuropeSub5380G=0.708A=0.292
The Genome Aggregation DatabaseGlobalStudy-wide9392G=0.672A=0.328
The Genome Aggregation DatabaseOtherSub84G=0.800A=0.200
PMID Title Author Journal
29071344Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Zhou HJAMA Psychiatry

P-Value

SNP ID p-value Traits Study
rs583352666E-06alcohol dependence29071344

eQTL of rs58335266 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs58335266 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2198360488198360561E067-9779
chr2198360626198360712E067-9628
chr2198360877198360917E067-9423
chr2198361174198361218E067-9122
chr2198361568198361612E067-8728
chr2198361780198361871E067-8469
chr2198362103198362393E067-7947
chr2198367031198367277E067-3063
chr2198367486198367530E067-2810
chr2198403247198403593E06732907
chr2198360260198360343E068-9997
chr2198360488198360561E068-9779
chr2198360626198360712E068-9628
chr2198360877198360917E068-9423
chr2198361174198361218E068-9122
chr2198361568198361612E068-8728
chr2198361780198361871E068-8469
chr2198362103198362393E068-7947
chr2198367031198367277E068-3063
chr2198403247198403593E06832907
chr2198403652198403704E06833312
chr2198360626198360712E069-9628
chr2198360877198360917E069-9423
chr2198361174198361218E069-9122
chr2198361568198361612E069-8728
chr2198361780198361871E069-8469
chr2198362103198362393E069-7947
chr2198362464198362514E069-7826
chr2198362531198362693E069-7647
chr2198367031198367277E069-3063
chr2198398457198398568E06928117
chr2198398689198398813E06928349
chr2198403247198403593E06932907
chr2198360488198360561E070-9779
chr2198360626198360712E070-9628
chr2198360877198360917E070-9423
chr2198361174198361218E070-9122
chr2198361568198361612E070-8728
chr2198361780198361871E070-8469
chr2198362103198362393E070-7947
chr2198362464198362514E070-7826
chr2198324188198324242E071-46098
chr2198324375198324425E071-45915
chr2198360488198360561E071-9779
chr2198360626198360712E071-9628
chr2198360877198360917E071-9423
chr2198361174198361218E071-9122
chr2198361568198361612E071-8728
chr2198361780198361871E071-8469
chr2198362103198362393E071-7947
chr2198403247198403593E07132907
chr2198403652198403704E07133312
chr2198407026198407090E07136686
chr2198360488198360561E072-9779
chr2198360626198360712E072-9628
chr2198360877198360917E072-9423
chr2198361174198361218E072-9122
chr2198361568198361612E072-8728
chr2198361780198361871E072-8469
chr2198362103198362393E072-7947
chr2198362464198362514E072-7826
chr2198362531198362693E072-7647
chr2198403247198403593E07232907
chr2198320370198320424E073-49916
chr2198362464198362514E073-7826
chr2198362531198362693E073-7647
chr2198367031198367277E073-3063
chr2198360877198360917E074-9423
chr2198361174198361218E074-9122
chr2198361568198361612E074-8728
chr2198361780198361871E074-8469
chr2198362103198362393E074-7947
chr2198362464198362514E074-7826
chr2198362531198362693E074-7647
chr2198367031198367277E074-3063
chr2198398457198398568E07428117
chr2198398689198398813E07428349
chr2198403247198403593E07432907
chr2198403652198403704E07433312
chr2198361174198361218E082-9122
chr2198361568198361612E082-8728
chr2198361780198361871E082-8469
chr2198362103198362393E082-7947
chr2198362464198362514E082-7826









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2198363378198363426E067-6914
chr2198363518198365878E067-4462
chr2198365950198366008E067-4332
chr2198366127198366216E067-4124
chr2198379473198381572E0679133
chr2198381598198381775E06711258
chr2198363378198363426E068-6914
chr2198363518198365878E068-4462
chr2198365950198366008E068-4332
chr2198366127198366216E068-4124
chr2198379473198381572E0689133
chr2198381598198381775E06811258
chr2198363378198363426E069-6914
chr2198363518198365878E069-4462
chr2198365950198366008E069-4332
chr2198366127198366216E069-4124
chr2198379473198381572E0699133
chr2198381598198381775E06911258
chr2198363378198363426E070-6914
chr2198363518198365878E070-4462
chr2198365950198366008E070-4332
chr2198366127198366216E070-4124
chr2198379473198381572E0709133
chr2198381598198381775E07011258
chr2198363378198363426E071-6914
chr2198363518198365878E071-4462
chr2198365950198366008E071-4332
chr2198366127198366216E071-4124
chr2198379473198381572E0719133
chr2198381598198381775E07111258
chr2198363378198363426E072-6914
chr2198363518198365878E072-4462
chr2198365950198366008E072-4332
chr2198366127198366216E072-4124
chr2198379473198381572E0729133
chr2198381598198381775E07211258
chr2198363378198363426E073-6914
chr2198363518198365878E073-4462
chr2198365950198366008E073-4332
chr2198366127198366216E073-4124
chr2198379473198381572E0739133
chr2198381598198381775E07311258
chr2198363378198363426E074-6914
chr2198363518198365878E074-4462
chr2198365950198366008E074-4332
chr2198366127198366216E074-4124
chr2198379473198381572E0749133
chr2198381598198381775E07411258
chr2198363378198363426E081-6914
chr2198365950198366008E081-4332
chr2198366127198366216E081-4124
chr2198379473198381572E0819133
chr2198381598198381775E08111258
chr2198363378198363426E082-6914
chr2198363518198365878E082-4462
chr2198365950198366008E082-4332
chr2198366127198366216E082-4124
chr2198379473198381572E0829133
chr2198381598198381775E08211258